TY - JOUR
T1 - Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates
AU - Xia, Yan
AU - Li, Ming
AU - Charubin, Kamil
AU - Liu, Ying
AU - Heberle, Frederick A.
AU - Katsaras, John
AU - Jing, Benxin
AU - Zhu, Yingxi
AU - Nieh, Mu Ping
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/11/5
Y1 - 2015/11/5
N2 - We report on studies of lipid transfer rates between different morphology nanoparticles and lipids with different length acyl chains. The lipid transfer rate of dimyristoylphosphatidylcholine (di-C14, DMPC) in discoidal "bicelles" (0.156 h-1) is 2 orders of magnitude greater than that of DMPC vesicles (ULVs) (1.1 × 10-3 h-1). For both bicellar and ULV morphologies, increasing the acyl chain length by two carbons [going from di-C14 DMPC to di-C16, dipalmitoylphosphatidylcholine (DPPC)] causes lipid transfer rates to decrease by more than 2 orders of magnitude. Results from small angle neutron scattering (SANS), differential scanning calorimetry (DSC), and fluorescence correlation spectroscopy (FCS) are in good agreement. The present studies highlight the importance of lipid dynamic processes taking place in different morphology biomimetic membranes.
AB - We report on studies of lipid transfer rates between different morphology nanoparticles and lipids with different length acyl chains. The lipid transfer rate of dimyristoylphosphatidylcholine (di-C14, DMPC) in discoidal "bicelles" (0.156 h-1) is 2 orders of magnitude greater than that of DMPC vesicles (ULVs) (1.1 × 10-3 h-1). For both bicellar and ULV morphologies, increasing the acyl chain length by two carbons [going from di-C14 DMPC to di-C16, dipalmitoylphosphatidylcholine (DPPC)] causes lipid transfer rates to decrease by more than 2 orders of magnitude. Results from small angle neutron scattering (SANS), differential scanning calorimetry (DSC), and fluorescence correlation spectroscopy (FCS) are in good agreement. The present studies highlight the importance of lipid dynamic processes taking place in different morphology biomimetic membranes.
UR - http://www.scopus.com/inward/record.url?scp=84948466023&partnerID=8YFLogxK
U2 - 10.1021/acs.langmuir.5b03291
DO - 10.1021/acs.langmuir.5b03291
M3 - Article
C2 - 26540211
AN - SCOPUS:84948466023
SN - 0743-7463
VL - 31
SP - 12920
EP - 12928
JO - Langmuir
JF - Langmuir
IS - 47
ER -