Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Jeanette L. Gehrig; Siddarth Venkatesh; Hao Wei Chang; Matthew C. Hibberd; Vanderlene L. Kung; Jiye Cheng; Robert Y. Chen; Sathish Subramanian; Carrie A. Cowardin; Martin F. Meier; David O’Donnell; Michael Talcott; Larry D. Spears; Clay F. Semenkovich; Bernard Henrissat; Richard J. Giannone; Robert L. Hettich; Olga Ilkayeva; Michael Muehlbauer; Christopher B. Newgard; Christopher Sawyer; Richard D. Head; Dmitry A. Rodionov; Aleksandr A. Arzamasov; Semen A. Leyn; Andrei L. Osterman; Md Iqbal Hossain; Munirul Islam; Nuzhat Choudhury; Shafiqul Alam Sarker; Sayeeda Huq; Imteaz Mahmud; Ishita Mostafa; Mustafa Mahfuz; Michael J. Barratt; Tahmeed Ahmed; Jeffrey I. Gordon

doi:10.1126/science.aau4732

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Jeanette L. Gehrig, Siddarth Venkatesh, Hao Wei Chang, Matthew C. Hibberd, Vanderlene L. Kung, Jiye Cheng, Robert Y. Chen, Sathish Subramanian, Carrie A. Cowardin, Martin F. Meier, David O’Donnell, Michael Talcott, Larry D. Spears, Clay F. Semenkovich, Bernard Henrissat, Richard J. Giannone, Robert L. Hettich, Olga Ilkayeva, Michael Muehlbauer, Christopher B. NewgardChristopher Sawyer, Richard D. Head, Dmitry A. Rodionov, Aleksandr A. Arzamasov, Semen A. Leyn, Andrei L. Osterman, Md Iqbal Hossain, Munirul Islam, Nuzhat Choudhury, Shafiqul Alam Sarker, Sayeeda Huq, Imteaz Mahmud, Ishita Mostafa, Mustafa Mahfuz, Michael J. Barratt, Tahmeed Ahmed, Jeffrey I. Gordon

Bioanalytical Mass Spectrometry

Research output: Contribution to journal › Article › peer-review

291 Scopus citations

Abstract

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

Original language	English
Article number	Y
Journal	Science
Volume	365
Issue number	6449
DOIs	https://doi.org/10.1126/science.aau4732
State	Published - 2019

Funding

Funders	Funder number
National Institute of Arthritis and Musculoskeletal and Skin Diseases	P30AR057235

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gehrig, J. L., Venkatesh, S., Chang, H. W., Hibberd, M. C., Kung, V. L., Cheng, J., Chen, R. Y., Subramanian, S., Cowardin, C. A., Meier, M. F., O’Donnell, D., Talcott, M., Spears, L. D., Semenkovich, C. F., Henrissat, B., Giannone, R. J., Hettich, R. L., Ilkayeva, O., Muehlbauer, M., ... Gordon, J. I. (2019). Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science, 365(6449), Article Y. https://doi.org/10.1126/science.aau4732

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title = "Effects of microbiota-directed foods in gnotobiotic animals and undernourished children",

abstract = "To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.",

author = "Gehrig, {Jeanette L.} and Siddarth Venkatesh and Chang, {Hao Wei} and Hibberd, {Matthew C.} and Kung, {Vanderlene L.} and Jiye Cheng and Chen, {Robert Y.} and Sathish Subramanian and Cowardin, {Carrie A.} and Meier, {Martin F.} and David O{\textquoteright}Donnell and Michael Talcott and Spears, {Larry D.} and Semenkovich, {Clay F.} and Bernard Henrissat and Giannone, {Richard J.} and Hettich, {Robert L.} and Olga Ilkayeva and Michael Muehlbauer and Newgard, {Christopher B.} and Christopher Sawyer and Head, {Richard D.} and Rodionov, {Dmitry A.} and Arzamasov, {Aleksandr A.} and Leyn, {Semen A.} and Osterman, {Andrei L.} and Hossain, {Md Iqbal} and Munirul Islam and Nuzhat Choudhury and Sarker, {Shafiqul Alam} and Sayeeda Huq and Imteaz Mahmud and Ishita Mostafa and Mustafa Mahfuz and Barratt, {Michael J.} and Tahmeed Ahmed and Gordon, {Jeffrey I.}",

year = "2019",

doi = "10.1126/science.aau4732",

language = "English",

volume = "365",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6449",

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Gehrig, JL, Venkatesh, S, Chang, HW, Hibberd, MC, Kung, VL, Cheng, J, Chen, RY, Subramanian, S, Cowardin, CA, Meier, MF, O’Donnell, D, Talcott, M, Spears, LD, Semenkovich, CF, Henrissat, B, Giannone, RJ , Hettich, RL, Ilkayeva, O, Muehlbauer, M, Newgard, CB, Sawyer, C, Head, RD, Rodionov, DA, Arzamasov, AA, Leyn, SA, Osterman, AL, Hossain, MI, Islam, M, Choudhury, N, Sarker, SA, Huq, S, Mahmud, I, Mostafa, I, Mahfuz, M, Barratt, MJ, Ahmed, T & Gordon, JI 2019, 'Effects of microbiota-directed foods in gnotobiotic animals and undernourished children', Science, vol. 365, no. 6449, Y. https://doi.org/10.1126/science.aau4732

TY - JOUR

T1 - Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

AU - Gehrig, Jeanette L.

AU - Venkatesh, Siddarth

AU - Chang, Hao Wei

AU - Hibberd, Matthew C.

AU - Kung, Vanderlene L.

AU - Cheng, Jiye

AU - Chen, Robert Y.

AU - Subramanian, Sathish

AU - Cowardin, Carrie A.

AU - Meier, Martin F.

AU - O’Donnell, David

AU - Talcott, Michael

AU - Spears, Larry D.

AU - Semenkovich, Clay F.

AU - Henrissat, Bernard

AU - Giannone, Richard J.

AU - Hettich, Robert L.

AU - Ilkayeva, Olga

AU - Muehlbauer, Michael

AU - Newgard, Christopher B.

AU - Sawyer, Christopher

AU - Head, Richard D.

AU - Rodionov, Dmitry A.

AU - Arzamasov, Aleksandr A.

AU - Leyn, Semen A.

AU - Osterman, Andrei L.

AU - Hossain, Md Iqbal

AU - Islam, Munirul

AU - Choudhury, Nuzhat

AU - Sarker, Shafiqul Alam

AU - Huq, Sayeeda

AU - Mahmud, Imteaz

AU - Mostafa, Ishita

AU - Mahfuz, Mustafa

AU - Barratt, Michael J.

AU - Ahmed, Tahmeed

AU - Gordon, Jeffrey I.

PY - 2019

Y1 - 2019

N2 - To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

AB - To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

UR - http://www.scopus.com/inward/record.url?scp=85069056249&partnerID=8YFLogxK

U2 - 10.1126/science.aau4732

DO - 10.1126/science.aau4732

M3 - Article

C2 - 31296738

AN - SCOPUS:85069056249

SN - 0036-8075

VL - 365

JO - Science

JF - Science

IS - 6449

M1 - Y

ER -

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

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UN SDGs

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