Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications

Siva Sankar Sana; Ramakrishna Vadde; Raj Kumar; Sai Kumar Arla; Adinarayana Reddy Somala; K. S.V. Krishna Rao; Zhang Zhijun; Vijaya Kumar Naidu Boya; Kunal Mondal; Narsimha Mamidi

doi:10.1016/j.jddst.2023.104186

Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications

Siva Sankar Sana, Ramakrishna Vadde, Raj Kumar, Sai Kumar Arla, Adinarayana Reddy Somala, K. S.V. Krishna Rao, Zhang Zhijun, Vijaya Kumar Naidu Boya, Kunal Mondal, Narsimha Mamidi

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.

Original language	English
Article number	104186
Journal	Journal of Drug Delivery Science and Technology
Volume	80
DOIs	https://doi.org/10.1016/j.jddst.2023.104186
State	Published - Feb 2023
Externally published	Yes

Funding

All authors are thankful to Yogi Vemana University, India, and the North University of China, China, University of Nebraska Medical Center and Idaho National Laboratory, USA, and Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico.

Keywords

Biomedical
Biosynthesize
Drug delivery
Green synthesis
Metal oxide nanoparticles
Zinc oxide nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jddst.2023.104186

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Sana, S. S., Vadde, R., Kumar, R., Arla, S. K., Somala, A. R., Krishna Rao, K. S. V., Zhijun, Z., Boya, V. K. N., Mondal, K., & Mamidi, N. (2023). Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications. Journal of Drug Delivery Science and Technology, 80, Article 104186. https://doi.org/10.1016/j.jddst.2023.104186

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title = "Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications",

abstract = "Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.",

keywords = "Biomedical, Biosynthesize, Drug delivery, Green synthesis, Metal oxide nanoparticles, Zinc oxide nanoparticles",

author = "Sana, {Siva Sankar} and Ramakrishna Vadde and Raj Kumar and Arla, {Sai Kumar} and Somala, {Adinarayana Reddy} and {Krishna Rao}, {K. S.V.} and Zhang Zhijun and Boya, {Vijaya Kumar Naidu} and Kunal Mondal and Narsimha Mamidi",

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year = "2023",

month = feb,

doi = "10.1016/j.jddst.2023.104186",

language = "English",

volume = "80",

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Sana, SS, Vadde, R, Kumar, R, Arla, SK, Somala, AR, Krishna Rao, KSV, Zhijun, Z, Boya, VKN, Mondal, K & Mamidi, N 2023, 'Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications', Journal of Drug Delivery Science and Technology, vol. 80, 104186. https://doi.org/10.1016/j.jddst.2023.104186

TY - JOUR

T1 - Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications

AU - Sana, Siva Sankar

AU - Vadde, Ramakrishna

AU - Kumar, Raj

AU - Arla, Sai Kumar

AU - Somala, Adinarayana Reddy

AU - Krishna Rao, K. S.V.

AU - Zhijun, Zhang

AU - Boya, Vijaya Kumar Naidu

AU - Mondal, Kunal

AU - Mamidi, Narsimha

PY - 2023/2

Y1 - 2023/2

N2 - Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.

AB - Herein, we present a green and facile synthesis of zin oxide nanoparticles (ZnO-NPs) from Grewia flavescens (G. flavescens). The obtained ZnO-NPs display inherent antibacterial activity and controlled drug release profile under physiological conditions. The structural and optical characteristics of ZnO-NPs are thoroughly vetted by UV–vis spectroscopy, FT-IR, DLS, XRD, HR-TEM, and TGA. The morphological studies unveil that ZnO-NPs exhibit a spherical shape with an average size of 20–30 nm. The Hemolysis analysis reveals that ZnO-NPs display excellent biocompatibility against blood/RBC cells. In addition, ZnO-NPs exhibit excellent antimicrobial activity against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). In addition, curcumin-loaded ZnO-NPs are formulated and characterized to explore the drug-release behavior of ZnO-NPs. The ZnO-NPs exhibit sustained drug release. Specifically, rapid drug release is observed in the first 12 h followed by prolonged drug release is detected. Curcumin-loaded ZnO-NPs show significant cytotoxicity against human neuroblastoma SK-N-SH cells even at 250 μg/mL concentration. All these favorable properties of ZnO-NPs reveal that ZnO-NPs can be potential candidates for biomedical applications. Thus, we strongly believe that our eco-friendly strategy from leaf extract would be a practical method not only to produce ZnO-NPs but also for other metal oxide nanoparticles for biomedical applications and beyond.

KW - Biomedical

KW - Biosynthesize

KW - Drug delivery

KW - Green synthesis

KW - Metal oxide nanoparticles

KW - Zinc oxide nanoparticles

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U2 - 10.1016/j.jddst.2023.104186

DO - 10.1016/j.jddst.2023.104186

M3 - Article

AN - SCOPUS:85146870647

SN - 1773-2247

VL - 80

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

M1 - 104186

ER -

Eco-friendly and facile production of antibacterial zinc oxide nanoparticles from Grewia flavescens (G. flavescens) leaf extract for biomedical applications

Abstract

Funding

Keywords

UN SDGs

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