Dynamics of Phospholipid Membranes beyond Thermal Undulations

Sudipta Gupta; Judith U. De Mel; Rasangi M. Perera; Piotr Zolnierczuk; Markus Bleuel; Antonio Faraone; Gerald J. Schneider

doi:10.1021/acs.jpclett.8b01008

Dynamics of Phospholipid Membranes beyond Thermal Undulations

Sudipta Gupta, Judith U. De Mel, Rasangi M. Perera, Piotr Zolnierczuk, Markus Bleuel, Antonio Faraone, Gerald J. Schneider

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Abstract

We investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. We report the first experimental evidence of a short-range motion at the length scale of the size of the headgroup of a lipid. The associated mean squared displacement shows a t^0.26 dependence in the pico- to nanosecond region that indicates another process beyond the predictions of the Zilman-Granek (ZG) model (t^0.66) and translational diffusion (t¹). A comparison with theory shows that the observed low exponent is associated with a non-Gaussian transient trapping of lipid molecules in a local area and supports the continuous time random walk model. The analysis of the mean squared displacement leads to the important conclusion that the friction at the interface between water and liposomes plays a minor role. Center of mass diffusion of liposomes and transient trapping of lipids define the range in which the ZG model can be applied to analyze membrane fluctuations.

Original language	English
Pages (from-to)	2956-2960
Number of pages	5
Journal	Journal of Physical Chemistry Letters
Volume	9
Issue number	11
DOIs	https://doi.org/10.1021/acs.jpclett.8b01008
State	Published - Jun 7 2018
Externally published	Yes

Funding

The neutron scattering work is supported by the U.S. Department of Energy (DOE) under EPSCoR Grant No. DE-SC0012432 with additional support from the Louisiana Board of Regents. Access to the neutron spin echo spectrometer and small-angle scattering instruments was provided by the Center for High Resolution Neutron Scattering, a partnership between the National Institute of Standards and Technology and the National Science Foundation under Agreement No. DMR-1508249. Research conducted at the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL) was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. DOE. This paper was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof.

Funders	Funder number
Office of Basic Energy Sciences
Scientific User Facilities Division
U.S. DOE
National Science Foundation
U.S. Department of Energy
National Institute of Standards and Technology
Office of Experimental Program to Stimulate Competitive Research
Oak Ridge National Laboratory

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10.1021/acs.jpclett.8b01008

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abstract = "We investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. We report the first experimental evidence of a short-range motion at the length scale of the size of the headgroup of a lipid. The associated mean squared displacement shows a t0.26 dependence in the pico- to nanosecond region that indicates another process beyond the predictions of the Zilman-Granek (ZG) model (t0.66) and translational diffusion (t1). A comparison with theory shows that the observed low exponent is associated with a non-Gaussian transient trapping of lipid molecules in a local area and supports the continuous time random walk model. The analysis of the mean squared displacement leads to the important conclusion that the friction at the interface between water and liposomes plays a minor role. Center of mass diffusion of liposomes and transient trapping of lipids define the range in which the ZG model can be applied to analyze membrane fluctuations.",

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AU - Perera, Rasangi M.

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AU - Bleuel, Markus

AU - Faraone, Antonio

AU - Schneider, Gerald J.

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AB - We investigated the molecular dynamics of unilamellar liposomes by neutron spin echo spectroscopy. We report the first experimental evidence of a short-range motion at the length scale of the size of the headgroup of a lipid. The associated mean squared displacement shows a t0.26 dependence in the pico- to nanosecond region that indicates another process beyond the predictions of the Zilman-Granek (ZG) model (t0.66) and translational diffusion (t1). A comparison with theory shows that the observed low exponent is associated with a non-Gaussian transient trapping of lipid molecules in a local area and supports the continuous time random walk model. The analysis of the mean squared displacement leads to the important conclusion that the friction at the interface between water and liposomes plays a minor role. Center of mass diffusion of liposomes and transient trapping of lipids define the range in which the ZG model can be applied to analyze membrane fluctuations.

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Dynamics of Phospholipid Membranes beyond Thermal Undulations

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