Abstract
Electroporation (EP) is a phenomenon involving both nonlinear biophysical processes and complex geometries. When exposed to strong electric fields, the formation of pores within a cell membrane increases the membrane permeability. Discontinuous Galerkin (DG) finite element methods can directly enforce these flux jumps across the thin cell membrane interface. We implement a DG finite element method to model the electric field, pore formation, and transmembrane flux of charged solutes during EP. Our model is readily extensible for parallel computation on high performance clusters and agrees with previous reports.
Original language | English |
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Title of host publication | 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 |
Publisher | Institute of Electrical and Electronics Engineers Inc. |
Pages | 5850-5853 |
Number of pages | 4 |
ISBN (Electronic) | 9781538636466 |
DOIs | |
State | Published - Oct 26 2018 |
Externally published | Yes |
Event | 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States Duration: Jul 18 2018 → Jul 21 2018 |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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Volume | 2018-July |
ISSN (Print) | 1557-170X |
Conference
Conference | 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 |
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Country/Territory | United States |
City | Honolulu |
Period | 07/18/18 → 07/21/18 |
Funding
Submitted February 16th, 2018. Research supported by the National Science Foundation (DGE-0966125; CBET-1055913) and National Institutes of Health (R01CA213423) D. C. Sweeney and R. V. Davalos are with the Department of Biomedical Engineering and Mechanics at Virginia Tech, Blacksburg, VA, USA (correspondence e-mail: [email protected]) Fig. 1. A cell was modeled as a 2D axisymmetric sphere. (a) Diagram of the model geometry. The left side of the geometry is collinear with the axis of symmetry. (b) The 150 µm 75 µm triangular mesh included 588 elements that range in diameter from 0.84 µm to 20 µm.
Keywords
- Biotransport
- Discontinuous Galerkin
- Electroporation
- Finite Element