Direct visualization of hyaluronic acid polymer chain by self-assembled one-dimensional array of gold nanoparticles

Haeshin Lee; Seung Ho Choi; Tae Gwan Park

doi:10.1021/ma051929c

Direct visualization of hyaluronic acid polymer chain by self-assembled one-dimensional array of gold nanoparticles

Haeshin Lee, Seung Ho Choi, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Fabrication of one-dimensional array of gold nanoparticles, in which their self-assembly structures were dictated by a naturally occurring biopolymer, hyaluronic acid (HA), was investigated. The carboxylic acid groups of HA were chemically activated by 1-ethyl-3-(3-dimethylaminopropyl)-carboiimide hydrochloride (EDC) and 1-hydroxybenzotriazole (HOBT) and conjugated with cystamine dihydrochloride at pH 6.8 for 12 h. Transmission electron microscopy (TEM) was used to show the morphology of the Ha/Au nanoparticle array. Results show that direct visualization of a HA chain structure could be possible by the aligned gold nanoparticles in aqueous solution.

Original language	English
Pages (from-to)	23-25
Number of pages	3
Journal	Macromolecules
Volume	39
Issue number	1
DOIs	https://doi.org/10.1021/ma051929c
State	Published - Jan 10 2006
Externally published	Yes

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title = "Direct visualization of hyaluronic acid polymer chain by self-assembled one-dimensional array of gold nanoparticles",

abstract = "Fabrication of one-dimensional array of gold nanoparticles, in which their self-assembly structures were dictated by a naturally occurring biopolymer, hyaluronic acid (HA), was investigated. The carboxylic acid groups of HA were chemically activated by 1-ethyl-3-(3-dimethylaminopropyl)-carboiimide hydrochloride (EDC) and 1-hydroxybenzotriazole (HOBT) and conjugated with cystamine dihydrochloride at pH 6.8 for 12 h. Transmission electron microscopy (TEM) was used to show the morphology of the Ha/Au nanoparticle array. Results show that direct visualization of a HA chain structure could be possible by the aligned gold nanoparticles in aqueous solution.",

author = "Haeshin Lee and Choi, {Seung Ho} and Park, {Tae Gwan}",

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AU - Lee, Haeshin

AU - Choi, Seung Ho

AU - Park, Tae Gwan

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Y1 - 2006/1/10

N2 - Fabrication of one-dimensional array of gold nanoparticles, in which their self-assembly structures were dictated by a naturally occurring biopolymer, hyaluronic acid (HA), was investigated. The carboxylic acid groups of HA were chemically activated by 1-ethyl-3-(3-dimethylaminopropyl)-carboiimide hydrochloride (EDC) and 1-hydroxybenzotriazole (HOBT) and conjugated with cystamine dihydrochloride at pH 6.8 for 12 h. Transmission electron microscopy (TEM) was used to show the morphology of the Ha/Au nanoparticle array. Results show that direct visualization of a HA chain structure could be possible by the aligned gold nanoparticles in aqueous solution.

AB - Fabrication of one-dimensional array of gold nanoparticles, in which their self-assembly structures were dictated by a naturally occurring biopolymer, hyaluronic acid (HA), was investigated. The carboxylic acid groups of HA were chemically activated by 1-ethyl-3-(3-dimethylaminopropyl)-carboiimide hydrochloride (EDC) and 1-hydroxybenzotriazole (HOBT) and conjugated with cystamine dihydrochloride at pH 6.8 for 12 h. Transmission electron microscopy (TEM) was used to show the morphology of the Ha/Au nanoparticle array. Results show that direct visualization of a HA chain structure could be possible by the aligned gold nanoparticles in aqueous solution.

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Direct visualization of hyaluronic acid polymer chain by self-assembled one-dimensional array of gold nanoparticles

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