Dipole entropy based techniques for segmentation of introns and exons in DNA

Nithya Ramakrishnan, R. Bose

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We have used superinformation, which is a measure of the disorder of the entropy content of different portions of a sequence, to analyze the structural variations of the introns and exons in DNA. We have computed superinformation for the angles of the dipole moments of the base-pairs and nucleotides in the double and single-stranded forms of DNA, respectively. We show that the computed dipole-angular superinformation of the introns are significantly higher than those of the exons and that these techniques could be used for intron-exon segmentation. They also yield more accurate and computationally faster results than the previously reported methods.

Original languageEnglish
Article number083701
JournalApplied Physics Letters
Volume101
Issue number8
DOIs
StatePublished - Aug 20 2012
Externally publishedYes

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