Abstract
Dexamethasone nano-aggregate was prepared for the treatment of intimal hyperplasia caused by abnormal proliferation of smooth muscle cells. Triblock copolymers composed of poly(ethylene glycol) [PEG] and poly(d,l-lactic acid) [PLA] were synthesized with different chain lengths of PEG. Triblock copolymers in organic phase were mixed with dexamethasone and dexamethasone nano-aggregates was prepared by dispersing the organic phase into water. The average diameter of the nano-aggregates ranged from 200 to 300 nm. Dexamethasone was released out from the nano-aggregates and the release profile was dependent on PEG chain lengths. The dexamethasone nano-aggregates showed superior anti-proliferation effects on smooth muscle cells compared to dexamethasone. Flow cytometry showed that smooth muscle cells treated with dexamethasone nano-aggregates was arrested at a dormant phase in a dose-dependent manner. The dexamethasone nano-aggregates are expected to be a potent candidate for anti-proliferating smooth muscle tissues after a balloon-catheter treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 169-173 |
| Number of pages | 5 |
| Journal | International Journal of Pharmaceutics |
| Volume | 326 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Dec 1 2006 |
| Externally published | Yes |
Funding
This research was supported by Kangwon National University.
| Funders | Funder number |
|---|---|
| Kangwon National University |
Keywords
- Anti-proliferation
- Dexamethasone
- Nano-aggregate
- Smooth muscle cell