Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

A. G. Weisenberger; B. Kross; S. S. Gleason; J. Goddard; S. Majewski; S. R. Meikle; M. J. Paulus; M. Pomper; V. Popov; M. F. Smith; B. L. Welch; R. Wojcik

doi:10.1109/nssmic.2003.1352292

Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

A. G. Weisenberger
, B. Kross
, S. S. Gleason
, J. Goddard
, S. Majewski
, S. R. Meikle
, M. J. Paulus
, M. Pomper
, V. Popov
, M. F. Smith
, B. L. Welch
, R. Wojcik

Office of Lab Dir - Science & Technology

Research output: Contribution to journal › Conference article › peer-review

13 Scopus citations

Abstract

The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.

Original language	English
Article number	M6-47
Pages (from-to)	2090-2094
Number of pages	5
Journal	IEEE Nuclear Science Symposium Conference Record
Volume	3
DOIs	https://doi.org/10.1109/nssmic.2003.1352292
State	Published - 2003
Event	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States Duration: Oct 19 2003 → Oct 25 2003

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Weisenberger, A. G., Kross, B., Gleason, S. S., Goddard, J., Majewski, S., Meikle, S. R., Paulus, M. J., Pomper, M., Popov, V., Smith, M. F., Welch, B. L., & Wojcik, R. (2003). Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking. IEEE Nuclear Science Symposium Conference Record, 3, 2090-2094. Article M6-47. https://doi.org/10.1109/nssmic.2003.1352292

@article{e931d42118b04e3789c9f11ada9c6cb4,

title = "Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking",

abstract = "The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.",

author = "Weisenberger, \{A. G.\} and B. Kross and Gleason, \{S. S.\} and J. Goddard and S. Majewski and Meikle, \{S. R.\} and Paulus, \{M. J.\} and M. Pomper and V. Popov and Smith, \{M. F.\} and Welch, \{B. L.\} and R. Wojcik",

year = "2003",

doi = "10.1109/nssmic.2003.1352292",

language = "English",

volume = "3",

pages = "2090--2094",

journal = "IEEE Nuclear Science Symposium Conference Record",

issn = "1095-7863",

note = "2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference ; Conference date: 19-10-2003 Through 25-10-2003",

}

Weisenberger, AG, Kross, B, Gleason, SS, Goddard, J, Majewski, S, Meikle, SR, Paulus, MJ, Pomper, M, Popov, V, Smith, MF, Welch, BL & Wojcik, R 2003, 'Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking', IEEE Nuclear Science Symposium Conference Record, vol. 3, M6-47, pp. 2090-2094. https://doi.org/10.1109/nssmic.2003.1352292

TY - JOUR

T1 - Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

AU - Weisenberger, A. G.

AU - Kross, B.

AU - Gleason, S. S.

AU - Goddard, J.

AU - Majewski, S.

AU - Meikle, S. R.

AU - Paulus, M. J.

AU - Pomper, M.

AU - Popov, V.

AU - Smith, M. F.

AU - Welch, B. L.

AU - Wojcik, R.

PY - 2003

Y1 - 2003

N2 - The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.

AB - The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.

UR - https://www.scopus.com/pages/publications/19944427108

U2 - 10.1109/nssmic.2003.1352292

DO - 10.1109/nssmic.2003.1352292

M3 - Conference article

AN - SCOPUS:19944427108

SN - 1095-7863

VL - 3

SP - 2090

EP - 2094

JO - IEEE Nuclear Science Symposium Conference Record

JF - IEEE Nuclear Science Symposium Conference Record

M1 - M6-47

T2 - 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference

Y2 - 19 October 2003 through 25 October 2003

ER -

Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

Abstract

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