Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

A. G. Weisenberger; B. Kross; S. S. Gleason; J. Goddard; S. Majewski; S. R. Meikle; M. J. Paulus; M. Pomper; V. Popov; M. F. Smith; B. L. Welch; R. Wojcik

doi:10.1109/nssmic.2003.1352292

Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

A. G. Weisenberger, B. Kross, S. S. Gleason, J. Goddard, S. Majewski, S. R. Meikle, M. J. Paulus, M. Pomper, V. Popov, M. F. Smith, B. L. Welch, R. Wojcik

Research output: Contribution to journal › Conference article › peer-review

13 Scopus citations

Abstract

The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.

Original language	English
Article number	M6-47
Pages (from-to)	2090-2094
Number of pages	5
Journal	IEEE Nuclear Science Symposium Conference Record
Volume	3
DOIs	https://doi.org/10.1109/nssmic.2003.1352292
State	Published - 2003
Event	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States Duration: Oct 19 2003 → Oct 25 2003

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Weisenberger, A. G., Kross, B., Gleason, S. S., Goddard, J., Majewski, S., Meikle, S. R., Paulus, M. J., Pomper, M., Popov, V., Smith, M. F., Welch, B. L., & Wojcik, R. (2003). Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking. IEEE Nuclear Science Symposium Conference Record, 3, 2090-2094. Article M6-47. https://doi.org/10.1109/nssmic.2003.1352292

@article{e931d42118b04e3789c9f11ada9c6cb4,

title = "Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking",

abstract = "The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.",

author = "Weisenberger, {A. G.} and B. Kross and Gleason, {S. S.} and J. Goddard and S. Majewski and Meikle, {S. R.} and Paulus, {M. J.} and M. Pomper and V. Popov and Smith, {M. F.} and Welch, {B. L.} and R. Wojcik",

year = "2003",

doi = "10.1109/nssmic.2003.1352292",

language = "English",

volume = "3",

pages = "2090--2094",

journal = "IEEE Nuclear Science Symposium Conference Record",

issn = "1095-7863",

note = "2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference ; Conference date: 19-10-2003 Through 25-10-2003",

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Weisenberger, AG, Kross, B, Gleason, SS, Goddard, J, Majewski, S, Meikle, SR, Paulus, MJ, Pomper, M, Popov, V, Smith, MF, Welch, BL & Wojcik, R 2003, 'Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking', IEEE Nuclear Science Symposium Conference Record, vol. 3, M6-47, pp. 2090-2094. https://doi.org/10.1109/nssmic.2003.1352292

TY - JOUR

T1 - Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

AU - Weisenberger, A. G.

AU - Kross, B.

AU - Gleason, S. S.

AU - Goddard, J.

AU - Majewski, S.

AU - Meikle, S. R.

AU - Paulus, M. J.

AU - Pomper, M.

AU - Popov, V.

AU - Smith, M. F.

AU - Welch, B. L.

AU - Wojcik, R.

PY - 2003

Y1 - 2003

N2 - The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.

AB - The development and initial evaluation of a high-resolution single photon emission tomography (SPECT) based system to image the biodistribution of radiolabeled tracers such as Tc-99m and I-125 in unrestrained/un-anesthetized mice. An infrared (IR) based position tracking apparatus has been developed and integrated into a SPECT gantry. The tracking system is designed to measure the spatial position of a mouse's head at a rate of 10-15 frames per second with sub-millimeter accuracy. The High resolution, gamma imaging detectors are based on pixellated Nal(Tl) crystal scintillator arrays, arrays of compact position-sensitive photomultiplier tubes and novel readout circuitry for lower device cost while retaining high spatial resolution. Two SPECT gamma camera detector heads based on a 4 × 8 array of Hamamatsu R8520-C12 position sensitive photomultiplier tubes have been built and installed onto the gantry. The IR landmark-based pose measurement and tracking system is under development to provide animal position data during a SPECT scan. The animal position and orientation data acquired by the IR tracking system is used for motion correction during the tomographic image reconstruction.

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U2 - 10.1109/nssmic.2003.1352292

DO - 10.1109/nssmic.2003.1352292

M3 - Conference article

AN - SCOPUS:19944427108

SN - 1095-7863

VL - 3

SP - 2090

EP - 2094

JO - IEEE Nuclear Science Symposium Conference Record

JF - IEEE Nuclear Science Symposium Conference Record

M1 - M6-47

T2 - 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference

Y2 - 19 October 2003 through 25 October 2003

ER -

Development and testing of a restraint free small animal SPECT imaging system with infrared based motion tracking

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