Deuterium incorporation into cellulose: a mini-review of biological and chemical methods

Yan Song; Xianzhi Meng; Wei Jiang; Barbara R. Evans; Haoxi Ben; Yuanming Zhang; Yunqiao Pu; Sai Venkatesh Pingali; Brian H. Davison; Sai Zhang; Guangting Han; Arthur J. Ragauskas

doi:10.1007/s10570-022-04551-4

Deuterium incorporation into cellulose: a mini-review of biological and chemical methods

Yan Song, Xianzhi Meng, Wei Jiang, Barbara R. Evans, Haoxi Ben, Yuanming Zhang, Yunqiao Pu, Sai Venkatesh Pingali, Brian H. Davison, Sai Zhang, Guangting Han, Arthur J. Ragauskas

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Abstract: Isotopic enrichment offers structural insights that are not easily accessible with natural abundance isotopic composition. Deuterated cellulose has attracted considerable attention in the field of neutron scattering studies, providing information about the dynamics, structure of cellulose and its interactions with other plant cell wall components. The deuteration of cellulose also allows the analysis of cellulose hydrogen bonds by FTIR or NMR techniques. The chemical structure of cellulose contains both exchangeable hydroxyl and non-exchangeable alkyl hydrogens. Deuterium incorporation can be divided into two classifications: biological route which incorporates both alkyl and hydroxyl bound deuterium, and chemical route which typically replaces hydroxyl-bound exchangeable hydrogen. The biological route involves cultivating plants or microorganisms in a deuterium-enriched medium. The chemical route typically involves an exchange reaction between hydroxyl-bound hydrogen and D₂O, often facilitating with an alkaline reagent. This review provides an overview of recent advances in deuteration methods and characterization as well as the application of deuterated cellulose. Graphical Abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	4269-4286
Number of pages	18
Journal	Cellulose
Volume	29
Issue number	8
DOIs	https://doi.org/10.1007/s10570-022-04551-4
State	Published - May 2022

Funding

This manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan ( http://energy.gov/downloads/doe-public-access-plan ) This research was supported by the Science Research Foundation of Dezhou University; the National Natural Science Foundation of China; the National Key Research and Development Program of Shangdong Province; State Key Laboratory of Bio-Fibers and Eco-Textiles; Special Foundation of Taishan Scholar Construction Program; and by the U. S. Department of Energy Office of Science. The authors (YS, WJ, HB, YZ, SZ, GH) acknowledge the support by Science Research Foundation of Dezhou University (2021xjrc207 and 2019xgrc04), National Natural Science Foundation of China (51903131), the National Key Research and Development Program of China (2017YFB0309702), Natural Science Foundation of Shandong Province (ZR2019QEM007 and ZR2020ME076), Key Research and Development Program of Shandong Province (2020CXGC011101), State Key Laboratory of Bio-Fibers and Eco-Textiles (Qingdao University) and Special Foundation of “Taishan Scholar” Construction Program. This study was also supported, in part, by the U. S. Department of Energy Office of Science through the Genomic Science Program, Office of Biological and Environmental Research, under contract FWP ERKP752. Use of transmission electron microscopy and ultramicrotomy was provided by the Center for Nanophase Materials Sciences (CNMS), a U. S. Department of Energy Office of Science User Facility at Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee, under proposal no. CNMS2016-R83. Oak Ridge National Laboratory is managed by UT Battelle, LLC, for the U. S. Department of Energy under Contract DE-AC05-00OR22725. The views and opinions of the authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. Neither the United States Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights.

Funders	Funder number
Center for Nanophase Materials Sciences
Oak Ridge, Tennessee	CNMS2016-R83
Science Research Foundation of Dezhou University	2021xjrc207, 2019xgrc04
Special Foundation of Taishan Scholar Construction Program
U. S. Department of Energy Office of Science
U.S. Department of Energy	DE-AC05-00OR22725
Biological and Environmental Research	FWP ERKP752
Oak Ridge National Laboratory
Key Technology Research and Development Program of Shandong	2020CXGC011101
UT-Battelle
National Natural Science Foundation of China	51903131
Natural Science Foundation of Shandong Province	ZR2020ME076, ZR2019QEM007
Qingdao University
National Key Research and Development Program of China	2017YFB0309702
State Key Laboratory of Bio-Fibers and Eco-Textiles

Keywords

Cellulose
Deuteration
Hydrogen–deuterium exchange
Neutron diffraction

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10.1007/s10570-022-04551-4

Cite this

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title = "Deuterium incorporation into cellulose: a mini-review of biological and chemical methods",

abstract = "Abstract: Isotopic enrichment offers structural insights that are not easily accessible with natural abundance isotopic composition. Deuterated cellulose has attracted considerable attention in the field of neutron scattering studies, providing information about the dynamics, structure of cellulose and its interactions with other plant cell wall components. The deuteration of cellulose also allows the analysis of cellulose hydrogen bonds by FTIR or NMR techniques. The chemical structure of cellulose contains both exchangeable hydroxyl and non-exchangeable alkyl hydrogens. Deuterium incorporation can be divided into two classifications: biological route which incorporates both alkyl and hydroxyl bound deuterium, and chemical route which typically replaces hydroxyl-bound exchangeable hydrogen. The biological route involves cultivating plants or microorganisms in a deuterium-enriched medium. The chemical route typically involves an exchange reaction between hydroxyl-bound hydrogen and D2O, often facilitating with an alkaline reagent. This review provides an overview of recent advances in deuteration methods and characterization as well as the application of deuterated cellulose. Graphical Abstract: [Figure not available: see fulltext.]",

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doi = "10.1007/s10570-022-04551-4",

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T2 - a mini-review of biological and chemical methods

AU - Song, Yan

AU - Meng, Xianzhi

AU - Jiang, Wei

AU - Evans, Barbara R.

AU - Ben, Haoxi

AU - Zhang, Yuanming

AU - Pu, Yunqiao

AU - Pingali, Sai Venkatesh

AU - Davison, Brian H.

AU - Zhang, Sai

AU - Han, Guangting

AU - Ragauskas, Arthur J.

PY - 2022/5

Y1 - 2022/5

N2 - Abstract: Isotopic enrichment offers structural insights that are not easily accessible with natural abundance isotopic composition. Deuterated cellulose has attracted considerable attention in the field of neutron scattering studies, providing information about the dynamics, structure of cellulose and its interactions with other plant cell wall components. The deuteration of cellulose also allows the analysis of cellulose hydrogen bonds by FTIR or NMR techniques. The chemical structure of cellulose contains both exchangeable hydroxyl and non-exchangeable alkyl hydrogens. Deuterium incorporation can be divided into two classifications: biological route which incorporates both alkyl and hydroxyl bound deuterium, and chemical route which typically replaces hydroxyl-bound exchangeable hydrogen. The biological route involves cultivating plants or microorganisms in a deuterium-enriched medium. The chemical route typically involves an exchange reaction between hydroxyl-bound hydrogen and D2O, often facilitating with an alkaline reagent. This review provides an overview of recent advances in deuteration methods and characterization as well as the application of deuterated cellulose. Graphical Abstract: [Figure not available: see fulltext.]

AB - Abstract: Isotopic enrichment offers structural insights that are not easily accessible with natural abundance isotopic composition. Deuterated cellulose has attracted considerable attention in the field of neutron scattering studies, providing information about the dynamics, structure of cellulose and its interactions with other plant cell wall components. The deuteration of cellulose also allows the analysis of cellulose hydrogen bonds by FTIR or NMR techniques. The chemical structure of cellulose contains both exchangeable hydroxyl and non-exchangeable alkyl hydrogens. Deuterium incorporation can be divided into two classifications: biological route which incorporates both alkyl and hydroxyl bound deuterium, and chemical route which typically replaces hydroxyl-bound exchangeable hydrogen. The biological route involves cultivating plants or microorganisms in a deuterium-enriched medium. The chemical route typically involves an exchange reaction between hydroxyl-bound hydrogen and D2O, often facilitating with an alkaline reagent. This review provides an overview of recent advances in deuteration methods and characterization as well as the application of deuterated cellulose. Graphical Abstract: [Figure not available: see fulltext.]

KW - Cellulose

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KW - Neutron diffraction

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Deuterium incorporation into cellulose: a mini-review of biological and chemical methods

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