Design and performance of a new SPECT detector for multimodality small animal imaging platforms

Derek W. Austin; Michael J. Paulus; Shaun S. Gleason; Robert A. Mintzer; Stefan B. Siegel; Said D. Figueroa; Timothy J. Hoffman; Jonathan S. Wall

doi:10.1109/NSSMIC.2006.356508

Design and performance of a new SPECT detector for multimodality small animal imaging platforms

Derek W. Austin
, Michael J. Paulus
, Shaun S. Gleason
, Robert A. Mintzer
, Stefan B. Siegel
, Said D. Figueroa
, Timothy J. Hoffman
, Jonathan S. Wall

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

17 Scopus citations

Abstract

A new detector for single photon emission computed tomography (SPECT) has been developed for the Siemens microCAT® II and Inveon Multimodality preclinical imaging systems. The detector provides an active imaging area of 15 cm × 15 cm. We review the design of this new SPECT detector and present some key performance characteristics. Integral and differential uniformity were 3.7% and 3.0%, respectively. Mean energy resolution for ^99mTc (140 keV) was 12.5%. Sensitivity as high as 1400 cps/MBq was measured for ^99mTc on a dual-detector system, and a spatial resolution of 0.7 mm (FWHM) was obtained using 0.5 mm single pinhole collimators. Additionally, we present data from representative preclinical SPECT studies acquired with single and multi-pinhole collimators and multiple isotopes. Reconstructed images demonstrate that this detector is capable of high-resolution SPECT for multimodality small animal imaging.

Original language	English
Title of host publication	2006 IEEE Nuclear Science Symposium - Conference Record
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	3008-3011
Number of pages	4
ISBN (Print)	1424405610, 9781424405619
DOIs	https://doi.org/10.1109/NSSMIC.2006.356508
State	Published - 2006
Externally published	Yes
Event	2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States Duration: Oct 29 2006 → Nov 4 2006

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Volume	5
ISSN (Print)	1095-7863

Conference

Conference	2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Country/Territory	United States
City	San Diego, CA
Period	10/29/06 → 11/4/06

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10.1109/NSSMIC.2006.356508

Cite this

Austin, D. W., Paulus, M. J., Gleason, S. S., Mintzer, R. A., Siegel, S. B., Figueroa, S. D., Hoffman, T. J., & Wall, J. S. (2006). Design and performance of a new SPECT detector for multimodality small animal imaging platforms. In 2006 IEEE Nuclear Science Symposium - Conference Record (pp. 3008-3011). Article 4179665 (IEEE Nuclear Science Symposium Conference Record; Vol. 5). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2006.356508

@inproceedings{8cd0a10a9b884829b45e8b37e00b5fa7,

title = "Design and performance of a new SPECT detector for multimodality small animal imaging platforms",

abstract = "A new detector for single photon emission computed tomography (SPECT) has been developed for the Siemens microCAT{\textregistered} II and Inveon Multimodality preclinical imaging systems. The detector provides an active imaging area of 15 cm × 15 cm. We review the design of this new SPECT detector and present some key performance characteristics. Integral and differential uniformity were 3.7\% and 3.0\%, respectively. Mean energy resolution for 99mTc (140 keV) was 12.5\%. Sensitivity as high as 1400 cps/MBq was measured for 99mTc on a dual-detector system, and a spatial resolution of 0.7 mm (FWHM) was obtained using 0.5 mm single pinhole collimators. Additionally, we present data from representative preclinical SPECT studies acquired with single and multi-pinhole collimators and multiple isotopes. Reconstructed images demonstrate that this detector is capable of high-resolution SPECT for multimodality small animal imaging.",

author = "Austin, \{Derek W.\} and Paulus, \{Michael J.\} and Gleason, \{Shaun S.\} and Mintzer, \{Robert A.\} and Siegel, \{Stefan B.\} and Figueroa, \{Said D.\} and Hoffman, \{Timothy J.\} and Wall, \{Jonathan S.\}",

year = "2006",

doi = "10.1109/NSSMIC.2006.356508",

language = "English",

isbn = "1424405610",

series = "IEEE Nuclear Science Symposium Conference Record",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "3008--3011",

booktitle = "2006 IEEE Nuclear Science Symposium - Conference Record",

note = "2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD ; Conference date: 29-10-2006 Through 04-11-2006",

}

Austin, DW, Paulus, MJ, Gleason, SS, Mintzer, RA, Siegel, SB, Figueroa, SD, Hoffman, TJ & Wall, JS 2006, Design and performance of a new SPECT detector for multimodality small animal imaging platforms. in 2006 IEEE Nuclear Science Symposium - Conference Record., 4179665, IEEE Nuclear Science Symposium Conference Record, vol. 5, Institute of Electrical and Electronics Engineers Inc., pp. 3008-3011, 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD, San Diego, CA, United States, 10/29/06. https://doi.org/10.1109/NSSMIC.2006.356508

Design and performance of a new SPECT detector for multimodality small animal imaging platforms. / Austin, Derek W.; Paulus, Michael J.; Gleason, Shaun S. et al.
2006 IEEE Nuclear Science Symposium - Conference Record. Institute of Electrical and Electronics Engineers Inc., 2006. p. 3008-3011 4179665 (IEEE Nuclear Science Symposium Conference Record; Vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

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AU - Austin, Derek W.

AU - Paulus, Michael J.

AU - Gleason, Shaun S.

AU - Mintzer, Robert A.

AU - Siegel, Stefan B.

AU - Figueroa, Said D.

AU - Hoffman, Timothy J.

AU - Wall, Jonathan S.

PY - 2006

Y1 - 2006

N2 - A new detector for single photon emission computed tomography (SPECT) has been developed for the Siemens microCAT® II and Inveon Multimodality preclinical imaging systems. The detector provides an active imaging area of 15 cm × 15 cm. We review the design of this new SPECT detector and present some key performance characteristics. Integral and differential uniformity were 3.7% and 3.0%, respectively. Mean energy resolution for 99mTc (140 keV) was 12.5%. Sensitivity as high as 1400 cps/MBq was measured for 99mTc on a dual-detector system, and a spatial resolution of 0.7 mm (FWHM) was obtained using 0.5 mm single pinhole collimators. Additionally, we present data from representative preclinical SPECT studies acquired with single and multi-pinhole collimators and multiple isotopes. Reconstructed images demonstrate that this detector is capable of high-resolution SPECT for multimodality small animal imaging.

AB - A new detector for single photon emission computed tomography (SPECT) has been developed for the Siemens microCAT® II and Inveon Multimodality preclinical imaging systems. The detector provides an active imaging area of 15 cm × 15 cm. We review the design of this new SPECT detector and present some key performance characteristics. Integral and differential uniformity were 3.7% and 3.0%, respectively. Mean energy resolution for 99mTc (140 keV) was 12.5%. Sensitivity as high as 1400 cps/MBq was measured for 99mTc on a dual-detector system, and a spatial resolution of 0.7 mm (FWHM) was obtained using 0.5 mm single pinhole collimators. Additionally, we present data from representative preclinical SPECT studies acquired with single and multi-pinhole collimators and multiple isotopes. Reconstructed images demonstrate that this detector is capable of high-resolution SPECT for multimodality small animal imaging.

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BT - 2006 IEEE Nuclear Science Symposium - Conference Record

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD

Y2 - 29 October 2006 through 4 November 2006

ER -

Austin DW, Paulus MJ, Gleason SS, Mintzer RA, Siegel SB, Figueroa SD et al. Design and performance of a new SPECT detector for multimodality small animal imaging platforms. In 2006 IEEE Nuclear Science Symposium - Conference Record. Institute of Electrical and Electronics Engineers Inc. 2006. p. 3008-3011. 4179665. (IEEE Nuclear Science Symposium Conference Record). doi: 10.1109/NSSMIC.2006.356508

Design and performance of a new SPECT detector for multimodality small animal imaging platforms

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