Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Yuki Hirakawa; Hidefumi Shinohara; Kai Welke; Stephan Irle; Yoshikatsu Matsubayashi; Keiko U. Torii; Naoyuki Uchida

doi:10.1038/ncomms14318

Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Yuki Hirakawa, Hidefumi Shinohara, Kai Welke, Stephan Irle, Yoshikatsu Matsubayashi, Keiko U. Torii, Naoyuki Uchida

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.

Original language	English
Article number	14318
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms14318
State	Published - Feb 6 2017
Externally published	Yes

Funding

This research was supported by MEXT/JSPS KAKENHI (grant numbers JP26113507, JP26291057 and JP16H01237 to K.U.T; JP25114511, JP26113707 and JP16H01462 to N.U.; JP25221105 and JP15H05957 to Y.M; JP26113520, JP16H01234 and JP25840111 to H.S.) and Howard Hughes Medical Institute (HHMI) and Gordon and Betty Moore Foundation (GBMF) (grant number GBMF3035 to K.U.T). K.U.T. is an HHMI-GBMF Investigator. Y.H. and K.W. are JSPS Postdoctoral Fellows. Y.H. was an HFSP Postdoctoral Fellow

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AU - Hirakawa, Yuki

AU - Shinohara, Hidefumi

AU - Welke, Kai

AU - Irle, Stephan

AU - Matsubayashi, Yoshikatsu

AU - Torii, Keiko U.

AU - Uchida, Naoyuki

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AB - Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.

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Cryptic bioactivity capacitated by synthetic hybrid plant peptides

Abstract

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