Cross-section measurements and production of                          72                         Se with medium to high energy protons using arsenic containing targets

Anthony J. Degraffenreid; Dmitri G. Medvedev; Timothy E. Phelps; Matthew D. Gott; Suzanne V. Smith; Silvia S. Jurisson; Cathy S. Cutler

doi:10.1515/ract-2018-2931

Cross-section measurements and production of ⁷² Se with medium to high energy protons using arsenic containing targets

Anthony J. Degraffenreid, Dmitri G. Medvedev, Timothy E. Phelps, Matthew D. Gott, Suzanne V. Smith, Silvia S. Jurisson, Cathy S. Cutler

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Experiments were performed to evaluate production of ⁷² Se, parent radionuclide of the positron emitter ⁷² As, at high energy at the Brookhaven Linac Isotope Producer (BLIP). Excitation functions for ⁷⁵ As(p, xn) ^72/75 Se in the 52-105 MeV energy range were measured by irradiating thin gallium arsenide (GaAs) wafers. Maximum cross section value for the ^nat As(p, 4n) ⁷² Se reaction in the energy range was 103±9 mb at 52±1 MeV. Production size GaAs and arsenic metal (As°) targets were irradiated with 136 μA and 165 μA beam current possessing an initial Linac energy of 117 MeV. A total of 3.77±0.1 GBq (102±3 mCi) of ⁷² Se was produced from a GaAs target at a calculated target entrance energy of 105.4 MeV, and 13.8±0.3 GBq (373±8 mCi) of ⁷² Se from an As° target at a calculated incident energy of 49.5 MeV irradiated for 116.5 h and 68.9 h, respectively.

Original language	English
Pages (from-to)	279-287
Number of pages	9
Journal	Radiochimica Acta
Volume	107
Issue number	4
DOIs	https://doi.org/10.1515/ract-2018-2931
State	Published - Apr 1 2019
Externally published	Yes

Funding

Acknowledgments: This study was supported by funding provided by the Department of Energy, Office of Nuclear Physics, subprogram Production of High Specific Activity (Funder Id: http://dx.doi.org/10.13039/100006147, DE-ST001020) and Brookhaven National Laboratory Isotope LDRD/Program Development (Funder Id: http:// dx.doi.org/10.13039/100006231, YN0100000). Trainee support is acknowledged from the National Science Foundation under IGERT award Funder Id: http://dx.doi. org/10.13039/100000001, DGE-0965983 (M.D. Gott and T.E. Phelps) and the Department of Energy Office of Science Graduate Student Research (SCGSR) award Funder Id: http://dx.doi.org/10.13039/100000015, DE-AC05-06OR23100 in 2014 (M. D. Gott) and 2015 (T.E. Phelps). The authors would also like to thank the Center for Functional Nanomaterials for its material analysis infrastructure related to thermal gravimetric analysis. A special thanks to Don Elliott from the instrumentation division at BNL for laser cutting GaAs targets, and the BLIP operator, TPL operators, quality assurance manager, and engineer (Jason Nalepa, Lisa Muench, Slawko Kurzak, Jack Eng, and Christian Cullen) involved with this project.

Keywords

As-72 generator
matched-pair
nuclear imaging
positron emission tomography
theragnostic
therapy

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10.1515/ract-2018-2931

Cite this

Degraffenreid, A. J., Medvedev, D. G., Phelps, T. E., Gott, M. D., Smith, S. V., Jurisson, S. S., & Cutler, C. S. (2019). Cross-section measurements and production of ⁷² Se with medium to high energy protons using arsenic containing targets Radiochimica Acta, 107(4), 279-287. https://doi.org/10.1515/ract-2018-2931

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title = " Cross-section measurements and production of 72 Se with medium to high energy protons using arsenic containing targets ",

abstract = " Experiments were performed to evaluate production of 72 Se, parent radionuclide of the positron emitter 72 As, at high energy at the Brookhaven Linac Isotope Producer (BLIP). Excitation functions for 75 As(p, xn) 72/75 Se in the 52-105 MeV energy range were measured by irradiating thin gallium arsenide (GaAs) wafers. Maximum cross section value for the nat As(p, 4n) 72 Se reaction in the energy range was 103±9 mb at 52±1 MeV. Production size GaAs and arsenic metal (As°) targets were irradiated with 136 μA and 165 μA beam current possessing an initial Linac energy of 117 MeV. A total of 3.77±0.1 GBq (102±3 mCi) of 72 Se was produced from a GaAs target at a calculated target entrance energy of 105.4 MeV, and 13.8±0.3 GBq (373±8 mCi) of 72 Se from an As° target at a calculated incident energy of 49.5 MeV irradiated for 116.5 h and 68.9 h, respectively.",

keywords = "As-72 generator, matched-pair, nuclear imaging, positron emission tomography, theragnostic, therapy",

author = "Degraffenreid, \{Anthony J.\} and Medvedev, \{Dmitri G.\} and Phelps, \{Timothy E.\} and Gott, \{Matthew D.\} and Smith, \{Suzanne V.\} and Jurisson, \{Silvia S.\} and Cutler, \{Cathy S.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Walter de Gruyter GmbH, Berlin/Boston 2019.",

year = "2019",

month = apr,

day = "1",

doi = "10.1515/ract-2018-2931",

language = "English",

volume = "107",

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Degraffenreid, AJ, Medvedev, DG, Phelps, TE, Gott, MD, Smith, SV, Jurisson, SS & Cutler, CS 2019, ' Cross-section measurements and production of ⁷² Se with medium to high energy protons using arsenic containing targets ', Radiochimica Acta, vol. 107, no. 4, pp. 279-287. https://doi.org/10.1515/ract-2018-2931

Cross-section measurements and production of ⁷² Se with medium to high energy protons using arsenic containing targets . / Degraffenreid, Anthony J.; Medvedev, Dmitri G.; Phelps, Timothy E. et al.
In: Radiochimica Acta, Vol. 107, No. 4, 01.04.2019, p. 279-287.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cross-section measurements and production of 72 Se with medium to high energy protons using arsenic containing targets

AU - Degraffenreid, Anthony J.

AU - Medvedev, Dmitri G.

AU - Phelps, Timothy E.

AU - Gott, Matthew D.

AU - Smith, Suzanne V.

AU - Jurisson, Silvia S.

AU - Cutler, Cathy S.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Experiments were performed to evaluate production of 72 Se, parent radionuclide of the positron emitter 72 As, at high energy at the Brookhaven Linac Isotope Producer (BLIP). Excitation functions for 75 As(p, xn) 72/75 Se in the 52-105 MeV energy range were measured by irradiating thin gallium arsenide (GaAs) wafers. Maximum cross section value for the nat As(p, 4n) 72 Se reaction in the energy range was 103±9 mb at 52±1 MeV. Production size GaAs and arsenic metal (As°) targets were irradiated with 136 μA and 165 μA beam current possessing an initial Linac energy of 117 MeV. A total of 3.77±0.1 GBq (102±3 mCi) of 72 Se was produced from a GaAs target at a calculated target entrance energy of 105.4 MeV, and 13.8±0.3 GBq (373±8 mCi) of 72 Se from an As° target at a calculated incident energy of 49.5 MeV irradiated for 116.5 h and 68.9 h, respectively.

AB - Experiments were performed to evaluate production of 72 Se, parent radionuclide of the positron emitter 72 As, at high energy at the Brookhaven Linac Isotope Producer (BLIP). Excitation functions for 75 As(p, xn) 72/75 Se in the 52-105 MeV energy range were measured by irradiating thin gallium arsenide (GaAs) wafers. Maximum cross section value for the nat As(p, 4n) 72 Se reaction in the energy range was 103±9 mb at 52±1 MeV. Production size GaAs and arsenic metal (As°) targets were irradiated with 136 μA and 165 μA beam current possessing an initial Linac energy of 117 MeV. A total of 3.77±0.1 GBq (102±3 mCi) of 72 Se was produced from a GaAs target at a calculated target entrance energy of 105.4 MeV, and 13.8±0.3 GBq (373±8 mCi) of 72 Se from an As° target at a calculated incident energy of 49.5 MeV irradiated for 116.5 h and 68.9 h, respectively.

KW - As-72 generator

KW - matched-pair

KW - nuclear imaging

KW - positron emission tomography

KW - theragnostic

KW - therapy

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DO - 10.1515/ract-2018-2931

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EP - 287

JO - Radiochimica Acta

JF - Radiochimica Acta

IS - 4

ER -