Creating nanocavities of tunable sizes: Hollow helices

Bing Gong; Huaqiang Zeng; Jin Zhu; Lihua Yuan; Yaohua Han; Shizhi Cheng; Mako Furukawa; Rubén D. Parra; Andrey Y. Kovalevsky; Jeffrey L. Mills; Ewa Skrzypczak-Jankun; Suzana Martinovic; Richard D. Smith; Chong Zheng; Thomas Szyperski; Xiao Cheng Zeng

doi:10.1073/pnas.162277099

Creating nanocavities of tunable sizes: Hollow helices

Bing Gong, Huaqiang Zeng, Jin Zhu, Lihua Yuan, Yaohua Han, Shizhi Cheng, Mako Furukawa, Rubén D. Parra, Andrey Y. Kovalevsky, Jeffrey L. Mills, Ewa Skrzypczak-Jankun, Suzana Martinovic, Richard D. Smith, Chong Zheng, Thomas Szyperski, Xiao Cheng Zeng

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

A general strategy for creating nanocavities with tunable sizes based on the folding of unnatural oligomers is presented. The backbones of these oligomers are rigidified by localized, three-center intramolecular hydrogen bonds, which lead to well-defined hollow helical conformations. Changing the curvature of the oligomer backbone leads to the adjustment of the interior cavity size. Helices with interior cavities of 10 Å to > 30 Å across, the largest thus far formed by the folding of unnatural foldamers, are generated. Cavities of these sizes are usually seen at the tertiary and quaternary structural levels of proteins. The ability to tune molecular dimensions without altering the underlying topology is seen in few natural and unnatural foldamer systems.

Original language	English
Pages (from-to)	11583-11588
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	18
DOIs	https://doi.org/10.1073/pnas.162277099
State	Published - Sep 3 2002
Externally published	Yes

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Gong, B., Zeng, H., Zhu, J., Yuan, L., Han, Y., Cheng, S., Furukawa, M., Parra, R. D., Kovalevsky, A. Y., Mills, J. L., Skrzypczak-Jankun, E., Martinovic, S., Smith, R. D., Zheng, C., Szyperski, T., & Zeng, X. C. (2002). Creating nanocavities of tunable sizes: Hollow helices. Proceedings of the National Academy of Sciences of the United States of America, 99(18), 11583-11588. https://doi.org/10.1073/pnas.162277099

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title = "Creating nanocavities of tunable sizes: Hollow helices",

abstract = "A general strategy for creating nanocavities with tunable sizes based on the folding of unnatural oligomers is presented. The backbones of these oligomers are rigidified by localized, three-center intramolecular hydrogen bonds, which lead to well-defined hollow helical conformations. Changing the curvature of the oligomer backbone leads to the adjustment of the interior cavity size. Helices with interior cavities of 10 {\AA} to > 30 {\AA} across, the largest thus far formed by the folding of unnatural foldamers, are generated. Cavities of these sizes are usually seen at the tertiary and quaternary structural levels of proteins. The ability to tune molecular dimensions without altering the underlying topology is seen in few natural and unnatural foldamer systems.",

author = "Bing Gong and Huaqiang Zeng and Jin Zhu and Lihua Yuan and Yaohua Han and Shizhi Cheng and Mako Furukawa and Parra, {Rub{\'e}n D.} and Kovalevsky, {Andrey Y.} and Mills, {Jeffrey L.} and Ewa Skrzypczak-Jankun and Suzana Martinovic and Smith, {Richard D.} and Chong Zheng and Thomas Szyperski and Zeng, {Xiao Cheng}",

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doi = "10.1073/pnas.162277099",

language = "English",

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Gong, B, Zeng, H, Zhu, J, Yuan, L, Han, Y, Cheng, S, Furukawa, M, Parra, RD, Kovalevsky, AY, Mills, JL, Skrzypczak-Jankun, E, Martinovic, S, Smith, RD, Zheng, C, Szyperski, T & Zeng, XC 2002, 'Creating nanocavities of tunable sizes: Hollow helices', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 18, pp. 11583-11588. https://doi.org/10.1073/pnas.162277099

TY - JOUR

T1 - Creating nanocavities of tunable sizes

T2 - Hollow helices

AU - Gong, Bing

AU - Zeng, Huaqiang

AU - Zhu, Jin

AU - Yuan, Lihua

AU - Han, Yaohua

AU - Cheng, Shizhi

AU - Furukawa, Mako

AU - Parra, Rubén D.

AU - Kovalevsky, Andrey Y.

AU - Mills, Jeffrey L.

AU - Skrzypczak-Jankun, Ewa

AU - Martinovic, Suzana

AU - Smith, Richard D.

AU - Zheng, Chong

AU - Szyperski, Thomas

AU - Zeng, Xiao Cheng

PY - 2002/9/3

Y1 - 2002/9/3

N2 - A general strategy for creating nanocavities with tunable sizes based on the folding of unnatural oligomers is presented. The backbones of these oligomers are rigidified by localized, three-center intramolecular hydrogen bonds, which lead to well-defined hollow helical conformations. Changing the curvature of the oligomer backbone leads to the adjustment of the interior cavity size. Helices with interior cavities of 10 Å to > 30 Å across, the largest thus far formed by the folding of unnatural foldamers, are generated. Cavities of these sizes are usually seen at the tertiary and quaternary structural levels of proteins. The ability to tune molecular dimensions without altering the underlying topology is seen in few natural and unnatural foldamer systems.

AB - A general strategy for creating nanocavities with tunable sizes based on the folding of unnatural oligomers is presented. The backbones of these oligomers are rigidified by localized, three-center intramolecular hydrogen bonds, which lead to well-defined hollow helical conformations. Changing the curvature of the oligomer backbone leads to the adjustment of the interior cavity size. Helices with interior cavities of 10 Å to > 30 Å across, the largest thus far formed by the folding of unnatural foldamers, are generated. Cavities of these sizes are usually seen at the tertiary and quaternary structural levels of proteins. The ability to tune molecular dimensions without altering the underlying topology is seen in few natural and unnatural foldamer systems.

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AN - SCOPUS:18544386112

SN - 0027-8424

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 18

ER -

Creating nanocavities of tunable sizes: Hollow helices

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