COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop

Laure Alix Clerbaux; Núria Amigó; Maria João Amorim; Anna Bal-Price; Sofia Batista Leite; Anna Beronius; Gillina F.G. Bezemer; Ann Charlotte Bostroem; Annamaria Carusi; Sandra Coecke; Rachel Concha; Evangelos P. Daskalopoulos; Francesca Debernardi; Eizleayne Edrosa; Steve W. Edwards; Julija Filipovska; Natàlia Garcia-Reyero; Felicity N.E. Gavins; Sabina Halappanavar; Alan J. Hargreaves; Helena T. Hogberg; Mylène T. Huynh; Daniel Jacobson; Jonathan Josephs- Spaulding; Young Jun Kim; Hyun Joon Kong; Catharine E. Krebs; Ann Lam; Brigitte Landesmann; Adrienne Racanelli Layton; Yong Oh Lee; Donna S. Macmillan; Alberto Mantovani; Luigi Margiotta-Casaluci; Marvin Martens; Rosalinde Masereeuw; Sally A. Mayasich; Liang Merlin Mei; Holly Mortensen; Amalia Munoz; Penny Nymark; Elan Ohayon; Joshi Manoj Ojasi; Alicia Paini; Nikolaos Parissis; Surat Parvatam; Francesca Pistollato; Magdalini Sachana; Jorid Birkelund Sørli; Kristie M. Sullivan; Jukka Sund; Shihori Tanabe; Katya Tsaioun; Mathieu Vinken; Laura Viviani; Jennifer Waspe; Catherine Willett; Clemens Wittwehr

doi:10.14573/altex.2112161

COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop

Laure Alix Clerbaux, Núria Amigó, Maria João Amorim, Anna Bal-Price, Sofia Batista Leite, Anna Beronius, Gillina F.G. Bezemer, Ann Charlotte Bostroem, Annamaria Carusi, Sandra Coecke, Rachel Concha, Evangelos P. Daskalopoulos, Francesca Debernardi, Eizleayne Edrosa, Steve W. Edwards, Julija Filipovska, Natàlia Garcia-Reyero, Felicity N.E. Gavins, Sabina Halappanavar, Alan J. HargreavesHelena T. Hogberg, Mylène T. Huynh, Daniel Jacobson, Jonathan Josephs- Spaulding, Young Jun Kim, Hyun Joon Kong, Catharine E. Krebs, Ann Lam, Brigitte Landesmann, Adrienne Racanelli Layton, Yong Oh Lee, Donna S. Macmillan, Alberto Mantovani, Luigi Margiotta-Casaluci, Marvin Martens, Rosalinde Masereeuw, Sally A. Mayasich, Liang Merlin Mei, Holly Mortensen, Amalia Munoz, Penny Nymark, Elan Ohayon, Joshi Manoj Ojasi, Alicia Paini, Nikolaos Parissis, Surat Parvatam, Francesca Pistollato, Magdalini Sachana, Jorid Birkelund Sørli, Kristie M. Sullivan, Jukka Sund, Shihori Tanabe, Katya Tsaioun, Mathieu Vinken, Laura Viviani, Jennifer Waspe, Catherine Willett, Clemens Wittwehr

Computational and Predictive Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

Original language	English
Pages (from-to)	322-335
Number of pages	14
Journal	Altex
Volume	39
Issue number	2
DOIs	https://doi.org/10.14573/altex.2112161
State	Published - 2022

Funding

The CIAO project is steered by the Joint Research Centre of the European Commission (EC-JRC), the Humane Society International (HSI), and the Physicians Committee for Responsible Medicine (PCRM). For Jorid Birkelund Sørli, the research is supported by FIKA, Focused Research Effort on Chemicals in the Working Environment from the Danish Government. For Daniel Jacobson, this work was supported by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, managed by UT-Battelle, LLC for the US Department of Energy (LOIS:10074) and the National Institutes of Health 3RF1AG053303-01S2. Institutional Statement: This manuscript has been coauthored by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the U.S. Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/ downloads/doe-public-access-plan).

Funders	Funder number
FIKA
Focused Research Effort on Chemicals in the Working Environment
National Institutes of Health	3RF1AG053303-01S2
U.S. Department of Energy	LOIS:10074
National Institute of Environmental Health Sciences	ZIAES103367
Oak Ridge National Laboratory
UT-Battelle	DE-AC05-00OR22725

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.14573/altex.2112161

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Clerbaux, L. A., Amigó, N., Amorim, M. J., Bal-Price, A., Leite, S. B., Beronius, A., Bezemer, G. F. G., Bostroem, A. C., Carusi, A., Coecke, S., Concha, R., Daskalopoulos, E. P., Debernardi, F., Edrosa, E., Edwards, S. W., Filipovska, J., Garcia-Reyero, N., Gavins, F. N. E., Halappanavar, S., ... Wittwehr, C. (2022). COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop. Altex, 39(2), 322-335. https://doi.org/10.14573/altex.2112161

@article{1537a15937f648eebb5b35ffeac59afd,

title = "COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop",

abstract = "On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project {"}Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework{"} aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.",

author = "Clerbaux, {Laure Alix} and N{\'u}ria Amig{\'o} and Amorim, {Maria Jo{\~a}o} and Anna Bal-Price and Leite, {Sofia Batista} and Anna Beronius and Bezemer, {Gillina F.G.} and Bostroem, {Ann Charlotte} and Annamaria Carusi and Sandra Coecke and Rachel Concha and Daskalopoulos, {Evangelos P.} and Francesca Debernardi and Eizleayne Edrosa and Edwards, {Steve W.} and Julija Filipovska and Nat{\`a}lia Garcia-Reyero and Gavins, {Felicity N.E.} and Sabina Halappanavar and Hargreaves, {Alan J.} and Hogberg, {Helena T.} and Huynh, {Myl{\`e}ne T.} and Daniel Jacobson and {Josephs- Spaulding}, Jonathan and Kim, {Young Jun} and Kong, {Hyun Joon} and Krebs, {Catharine E.} and Ann Lam and Brigitte Landesmann and Layton, {Adrienne Racanelli} and Lee, {Yong Oh} and Macmillan, {Donna S.} and Alberto Mantovani and Luigi Margiotta-Casaluci and Marvin Martens and Rosalinde Masereeuw and Mayasich, {Sally A.} and Mei, {Liang Merlin} and Holly Mortensen and Amalia Munoz and Penny Nymark and Elan Ohayon and Ojasi, {Joshi Manoj} and Alicia Paini and Nikolaos Parissis and Surat Parvatam and Francesca Pistollato and Magdalini Sachana and S{\o}rli, {Jorid Birkelund} and Sullivan, {Kristie M.} and Jukka Sund and Shihori Tanabe and Katya Tsaioun and Mathieu Vinken and Laura Viviani and Jennifer Waspe and Catherine Willett and Clemens Wittwehr",

year = "2022",

doi = "10.14573/altex.2112161",

language = "English",

volume = "39",

pages = "322--335",

journal = "Altex",

issn = "1868-596X",

publisher = "ALTEX Edition",

number = "2",

}

Clerbaux, LA, Amigó, N, Amorim, MJ, Bal-Price, A, Leite, SB, Beronius, A, Bezemer, GFG, Bostroem, AC, Carusi, A, Coecke, S, Concha, R, Daskalopoulos, EP, Debernardi, F, Edrosa, E, Edwards, SW, Filipovska, J, Garcia-Reyero, N, Gavins, FNE, Halappanavar, S, Hargreaves, AJ, Hogberg, HT, Huynh, MT, Jacobson, D, Josephs- Spaulding, J, Kim, YJ, Kong, HJ, Krebs, CE, Lam, A, Landesmann, B, Layton, AR, Lee, YO, Macmillan, DS, Mantovani, A, Margiotta-Casaluci, L, Martens, M, Masereeuw, R, Mayasich, SA, Mei, LM, Mortensen, H, Munoz, A, Nymark, P, Ohayon, E, Ojasi, JM, Paini, A, Parissis, N, Parvatam, S, Pistollato, F, Sachana, M, Sørli, JB, Sullivan, KM, Sund, J, Tanabe, S, Tsaioun, K, Vinken, M, Viviani, L, Waspe, J, Willett, C & Wittwehr, C 2022, 'COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop', Altex, vol. 39, no. 2, pp. 322-335. https://doi.org/10.14573/altex.2112161

TY - JOUR

T1 - COVID-19 through Adverse Outcome Pathways

T2 - Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop

AU - Clerbaux, Laure Alix

AU - Amigó, Núria

AU - Amorim, Maria João

AU - Bal-Price, Anna

AU - Leite, Sofia Batista

AU - Beronius, Anna

AU - Bezemer, Gillina F.G.

AU - Bostroem, Ann Charlotte

AU - Carusi, Annamaria

AU - Coecke, Sandra

AU - Concha, Rachel

AU - Daskalopoulos, Evangelos P.

AU - Debernardi, Francesca

AU - Edrosa, Eizleayne

AU - Edwards, Steve W.

AU - Filipovska, Julija

AU - Garcia-Reyero, Natàlia

AU - Gavins, Felicity N.E.

AU - Halappanavar, Sabina

AU - Hargreaves, Alan J.

AU - Hogberg, Helena T.

AU - Huynh, Mylène T.

AU - Jacobson, Daniel

AU - Josephs- Spaulding, Jonathan

AU - Kim, Young Jun

AU - Kong, Hyun Joon

AU - Krebs, Catharine E.

AU - Lam, Ann

AU - Landesmann, Brigitte

AU - Layton, Adrienne Racanelli

AU - Lee, Yong Oh

AU - Macmillan, Donna S.

AU - Mantovani, Alberto

AU - Margiotta-Casaluci, Luigi

AU - Martens, Marvin

AU - Masereeuw, Rosalinde

AU - Mayasich, Sally A.

AU - Mei, Liang Merlin

AU - Mortensen, Holly

AU - Munoz, Amalia

AU - Nymark, Penny

AU - Ohayon, Elan

AU - Ojasi, Joshi Manoj

AU - Paini, Alicia

AU - Parissis, Nikolaos

AU - Parvatam, Surat

AU - Pistollato, Francesca

AU - Sachana, Magdalini

AU - Sørli, Jorid Birkelund

AU - Sullivan, Kristie M.

AU - Sund, Jukka

AU - Tanabe, Shihori

AU - Tsaioun, Katya

AU - Vinken, Mathieu

AU - Viviani, Laura

AU - Waspe, Jennifer

AU - Willett, Catherine

AU - Wittwehr, Clemens

PY - 2022

Y1 - 2022

N2 - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

AB - On April 28-29, 2021, 50 scientists from different fields of expertise met for the 3rd online CIAO workshop. The CIAO project "Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway (AOP) framework" aims at building a holistic assembly of the available scientific knowledge on COVID-19 using the AOP framework. An individual AOP depicts the disease progression from the initial contact with the SARS-CoV-2 virus through biological key events (KE) toward an adverse outcome such as respiratory distress, anosmia or multiorgan failure. Assembling the individual AOPs into a network highlights shared KEs as central biological nodes involved in multiple outcomes observed in COVID-19 patients. During the workshop, the KEs and AOPs established so far by the CIAO members were presented and positioned on a timeline of the disease course. Modulating factors influencing the progression and severity of the disease were also addressed as well as factors beyond purely biological phenomena. CIAO relies on an interdisciplinary crowdsourcing effort, therefore, approaches to expand the CIAO network by widening the crowd and reaching stakeholders were also discussed. To conclude the workshop, it was decided that the AOPs/KEs will be further consolidated, integrating virus variants and long COVID when relevant, while an outreach campaign will be launched to broaden the CIAO scientific crowd.

UR - http://www.scopus.com/inward/record.url?scp=85128487716&partnerID=8YFLogxK

U2 - 10.14573/altex.2112161

DO - 10.14573/altex.2112161

M3 - Article

C2 - 35032963

AN - SCOPUS:85128487716

SN - 1868-596X

VL - 39

SP - 322

EP - 335

JO - Altex

JF - Altex

IS - 2

ER -

COVID-19 through Adverse Outcome Pathways: Building Networks to Better Understand the Disease - 3rd CIAO AOP Design Workshop

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