Core-shell nanostructures: perspectives towards drug delivery applications

Raj Kumar, Kunal Mondal, Pritam Kumar Panda, Ajeet Kaushik, Reza Abolhassani, Rajeev Ahuja, Horst Günter Rubahn, Yogendra Kumar Mishra

Research output: Contribution to journalReview articlepeer-review

136 Scopus citations

Abstract

Nanosystems have shown encouraging outcomes and substantial progress in the areas of drug delivery and biomedical applications. However, the controlled and targeted delivery of drugs or genes can be limited due to their physicochemical and functional properties. In this regard, core-shell type nanoparticles are promising nanocarrier systems for controlled and targeted drug delivery applications. These functional nanoparticles are emerging as a particular class of nanosystems because of their unique advantages, including high surface area, and easy surface modification and functionalization. Such unique advantages can facilitate the use of core-shell nanoparticles for the selective mingling of two or more different functional properties in a single nanosystem to achieve the desired physicochemical properties that are essential for effective targeted drug delivery. Several types of core-shell nanoparticles, such as metallic, magnetic, silica-based, upconversion, and carbon-based core-shell nanoparticles, have been designed and developed for drug delivery applications. Keeping the scope, demand, and challenges in view, the present review explores state-of-the-art developments and advances in core-shell nanoparticle systems, the desired structure-property relationships, newly generated properties, the effects of parameter control, surface modification, and functionalization, and, last but not least, their promising applications in the fields of drug delivery, biomedical applications, and tissue engineering. This review also supports significant future research for developing multi-core and shell-based functional nanosystems to investigate nano-therapies that are needed for advanced, precise, and personalized healthcare systems.

Original languageEnglish
Pages (from-to)8992-9027
Number of pages36
JournalJournal of Materials Chemistry B
Volume8
Issue number39
DOIs
StatePublished - Oct 21 2020
Externally publishedYes

Funding

Dr Raj Kumar gratefully acknowledges the Bar-Ilan Institute for Nanotechnology and Advanced Materials (BINA) and Bar-Ilan University. Dr Raj Kumar is thankful to the Planning and Budgeting Committee (PBC) of the Council of Higher Education, Israel, for awarding the PBC-postdoctoral fellowship. Dr Kunal Mondal gratefully acknowledges the Energy & Environment S & T at the Idaho National Laboratory, USA for their support. Prof. Rajeev Ahuja acknowledges support from the Swedish Research Council (VR grant no. 2016-06014). This review was funded by a PBC (Planning and Budget Committee) Postdoctoral Fellowship to Raj Kumar by the Planning and Budget Committee of the Council of Higher Education, Israel.

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