Abstract
Three types of isomeric 2-substituted furo[3,2-b]pyridine, furo[2,3-b]pyridine and furo[3,2-c]pyridine were prepared using Pd/C-catalyzed heteroannulation of o-halopyridinols and terminal alkynes under copperand ligand-free conditions. We also demonstrated that double functionalization yielding 2,3-disubstituted furopyridines could be achieved through heteroannulation followed by bromination and Suzuki/Heck reactions. In addition, the use of recoverable Pd/C in the absence of a cocatalyst and ligand can aid in the development of greener chemical processes.
Original language | English |
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Pages (from-to) | 211-218 |
Number of pages | 8 |
Journal | Bulletin of the Korean Chemical Society |
Volume | 36 |
Issue number | 1 |
DOIs | |
State | Published - Jan 20 2015 |
Externally published | Yes |
Keywords
- Copper-and ligand free
- Furopyridine
- Heteroannulation
- Pd/C
- Terminal alkyne