Controlling degradation of acid-hydrolyzable pluronic hydrogels by physical entrapment of poly(lactic acid-co-glycolic acid) microspheres

Jun Bae Lee, Ki Woo Chun, Jun Jin Yoon, Tae Gwan Park

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Chemically crosslinked biodegradable hydrogels based on di-acrylated Pluronic F-127 tri-block copolymer were prepared by a photopolymerization method. Poly(lactic acid-co-glycolic acid) (PLGA) microspheres were physically entrapped within the Pluronic hydrogel in order to modulate the local pH environment by acidic degradation by-products of PLGA microspheres. The PLGA microspheres were slowly degraded to create an acidic microenvironment, which facilitated the cleavage of an acid-labile ester-linkage in the biodegradable Pluronic hydrogel network. The presence of PLGA microspheres accelerated the degradation of the Pluronic hydrogel and enhanced the protein release rate when protein was loaded in the hydrogel.

Original languageEnglish
Pages (from-to)957-962
Number of pages6
JournalMacromolecular Bioscience
Volume4
Issue number10
DOIs
StatePublished - Nov 20 2004
Externally publishedYes

Keywords

  • Biodegradable
  • PLGA microspheres
  • Photopolymerization
  • Pluronic hydrogels
  • Protein delivery

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