@inproceedings{5d44ee04b57a41e58280245b6eacc0dc,
title = "Controlled release of indomethacin from spray-dried chitosan microspheres containing microemulsion",
abstract = "Indomethacin microemulsion loaded chitosan microspheres (IMCMs) were prepared by a spray-drying technique. IMCMs were spheroids formed by aggregates of microspheres with sizes of ~8 μm, while indomethacin loaded chitosan microspheres (ICM) (control) did not show any agglomeration. Indomethacin (IDM) appeared to be in an amorphous state in both ICMs and IMCMs, confirmed by X-ray diffraction and differential scanning calorimetry. The encapsulation efficiency of IDM was higher in IMCM than ICM. IMCMs exhibited a pH independent and sustained release pattern with small burst effect, compared to ICMs. Thus, drug-in-microemulsion loaded polymeric microspheres could possibly provide a sustained release formulation.",
author = "Lee, {Jun Bae} and Chung, {Hyun Jung} and Somlak Kongmuang and Park, {Tae Gwan}",
year = "2008",
month = nov,
day = "7",
doi = "10.1021/bk-2008-0992.ch004",
language = "English",
isbn = "9780841274242",
series = "ACS Symposium Series",
publisher = "American Chemical Society",
pages = "57--67",
booktitle = "New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials",
}