Controlled release of alendronate from nitrogen-doped mesoporous carbon

Dipendu Saha; Amanda Spurri; Jihua Chen; Dale K. Hensley

doi:10.1016/j.micromeso.2016.04.014

Controlled release of alendronate from nitrogen-doped mesoporous carbon

Dipendu Saha, Amanda Spurri, Jihua Chen, Dale K. Hensley

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We have synthesized a nitrogen doped mesoporous carbon with the BET surface area of 1066 m²/g, total pore volume 0.6 cm³/g and nitrogen content of 0.5%. Total alendronate adsorption in this carbon was ∼5%. The release experiments were designed in four different media with sequential pH values of 1.2, 4.5, 6.8 and 7.4 for 3, 1, 3 and 5 h, respectively and at 37 °C to imitate the physiological conditions of stomach, duodenum, small intestine and colon, respectively. Release of the drug demonstrated a controlled fashion; only 20% of the drug was released in the media with pH = 1.2, whereas 64% of the drug was released in pH = 7.4. This is in contrary to pure alendronate that was completely dissolved within 30 min in the first release media (pH = 1.2) only. The relatively larger uptake of alendronate in this carbon and its sustained fashion of release can be attributed to the hydrogen bonding between the drug and the nitrogen functionalities on carbon surface. Based on this result, it can be inferred that this formulation may lower the side effects of oral delivery of alendronate.

Original language	English
Pages (from-to)	8-13
Number of pages	6
Journal	Microporous and Mesoporous Materials
Volume	229
DOIs	https://doi.org/10.1016/j.micromeso.2016.04.014
State	Published - Jul 15 2016

Funding

D.S. acknowledges the faculty development award from School of Engineering (SOE) of Widener University. A.S. acknowledges funding from SOE of Widener University for senior project , which contributed to the part of this study. The authors acknowledge the student undergraduate team members, including Tara Moken, Lauren Benham and Ather Malik for their assistance in the experiment. TEM (J.C.) and SEM (D.K.H.) experiments were conducted at the Center for Nanophase Materials Sciences, which is a DOE Office of Science User Facility.

Funders	Funder number
SOE of Widener University

Keywords

Alendronate
Controlled release
Mesoporous carbon
Nitrogen doping
Osteoporosis

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title = "Controlled release of alendronate from nitrogen-doped mesoporous carbon",

abstract = "We have synthesized a nitrogen doped mesoporous carbon with the BET surface area of 1066 m2/g, total pore volume 0.6 cm3/g and nitrogen content of 0.5%. Total alendronate adsorption in this carbon was ∼5%. The release experiments were designed in four different media with sequential pH values of 1.2, 4.5, 6.8 and 7.4 for 3, 1, 3 and 5 h, respectively and at 37 °C to imitate the physiological conditions of stomach, duodenum, small intestine and colon, respectively. Release of the drug demonstrated a controlled fashion; only 20% of the drug was released in the media with pH = 1.2, whereas 64% of the drug was released in pH = 7.4. This is in contrary to pure alendronate that was completely dissolved within 30 min in the first release media (pH = 1.2) only. The relatively larger uptake of alendronate in this carbon and its sustained fashion of release can be attributed to the hydrogen bonding between the drug and the nitrogen functionalities on carbon surface. Based on this result, it can be inferred that this formulation may lower the side effects of oral delivery of alendronate.",

keywords = "Alendronate, Controlled release, Mesoporous carbon, Nitrogen doping, Osteoporosis",

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AU - Spurri, Amanda

AU - Chen, Jihua

AU - Hensley, Dale K.

PY - 2016/7/15

Y1 - 2016/7/15

N2 - We have synthesized a nitrogen doped mesoporous carbon with the BET surface area of 1066 m2/g, total pore volume 0.6 cm3/g and nitrogen content of 0.5%. Total alendronate adsorption in this carbon was ∼5%. The release experiments were designed in four different media with sequential pH values of 1.2, 4.5, 6.8 and 7.4 for 3, 1, 3 and 5 h, respectively and at 37 °C to imitate the physiological conditions of stomach, duodenum, small intestine and colon, respectively. Release of the drug demonstrated a controlled fashion; only 20% of the drug was released in the media with pH = 1.2, whereas 64% of the drug was released in pH = 7.4. This is in contrary to pure alendronate that was completely dissolved within 30 min in the first release media (pH = 1.2) only. The relatively larger uptake of alendronate in this carbon and its sustained fashion of release can be attributed to the hydrogen bonding between the drug and the nitrogen functionalities on carbon surface. Based on this result, it can be inferred that this formulation may lower the side effects of oral delivery of alendronate.

AB - We have synthesized a nitrogen doped mesoporous carbon with the BET surface area of 1066 m2/g, total pore volume 0.6 cm3/g and nitrogen content of 0.5%. Total alendronate adsorption in this carbon was ∼5%. The release experiments were designed in four different media with sequential pH values of 1.2, 4.5, 6.8 and 7.4 for 3, 1, 3 and 5 h, respectively and at 37 °C to imitate the physiological conditions of stomach, duodenum, small intestine and colon, respectively. Release of the drug demonstrated a controlled fashion; only 20% of the drug was released in the media with pH = 1.2, whereas 64% of the drug was released in pH = 7.4. This is in contrary to pure alendronate that was completely dissolved within 30 min in the first release media (pH = 1.2) only. The relatively larger uptake of alendronate in this carbon and its sustained fashion of release can be attributed to the hydrogen bonding between the drug and the nitrogen functionalities on carbon surface. Based on this result, it can be inferred that this formulation may lower the side effects of oral delivery of alendronate.

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KW - Osteoporosis

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Controlled release of alendronate from nitrogen-doped mesoporous carbon

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