Conjugation approach of drug to biodegradable poly(D,L-lactic-CO-glycolic acid) for controlled release from microspheres

Yoon Sung Nam; Keun Hyeung Lee; Tae Gwan Park

Conjugation approach of drug to biodegradable poly(D,L-lactic-CO-glycolic acid) for controlled release from microspheres

Yoon Sung Nam, Keun Hyeung Lee, Tae Gwan Park

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

A new approach of controlled release of two hydrophilic model drugs, lysozyme and protected tryptophan (Fmoc-Trp(Boc)), from poly(D,L-lactic-co-glycolic acid) [PLGA] microspheres was attempted. The novel formulation strategy is based on the hypothesis that lysozyme can not be released from microspheres until the PLGA polymer chain gradually degrades and reaches to a critical molecular weight at which the water solubility of lysozyme-PLGA oligomer conjugate is sufficiently gained. The drug-PLGA conjugates were formulated into microspheres by a single O/W emulsion method. The drug release kinetic behaviors from the conjugated drug loaded microspheres were compared with those from the conventional unconjugated drug loaded microspheres.

Original language	English
Pages (from-to)	216-217
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	39
Issue number	2
State	Published - Aug 1998
Externally published	Yes
Event	Proceedings of the 1997 Boston Meeting - Boston, MA, USA Duration: Aug 23 1998 → Aug 27 1998

Cite this

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title = "Conjugation approach of drug to biodegradable poly(D,L-lactic-CO-glycolic acid) for controlled release from microspheres",

abstract = "A new approach of controlled release of two hydrophilic model drugs, lysozyme and protected tryptophan (Fmoc-Trp(Boc)), from poly(D,L-lactic-co-glycolic acid) [PLGA] microspheres was attempted. The novel formulation strategy is based on the hypothesis that lysozyme can not be released from microspheres until the PLGA polymer chain gradually degrades and reaches to a critical molecular weight at which the water solubility of lysozyme-PLGA oligomer conjugate is sufficiently gained. The drug-PLGA conjugates were formulated into microspheres by a single O/W emulsion method. The drug release kinetic behaviors from the conjugated drug loaded microspheres were compared with those from the conventional unconjugated drug loaded microspheres.",

author = "Nam, {Yoon Sung} and Lee, {Keun Hyeung} and Park, {Tae Gwan}",

year = "1998",

month = aug,

language = "English",

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pages = "216--217",

journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

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number = "2",

note = "Proceedings of the 1997 Boston Meeting ; Conference date: 23-08-1998 Through 27-08-1998",

}

Conjugation approach of drug to biodegradable poly(D,L-lactic-CO-glycolic acid) for controlled release from microspheres. / Nam, Yoon Sung; Lee, Keun Hyeung; Park, Tae Gwan.
In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 39, No. 2, 08.1998, p. 216-217.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Conjugation approach of drug to biodegradable poly(D,L-lactic-CO-glycolic acid) for controlled release from microspheres

AU - Nam, Yoon Sung

AU - Lee, Keun Hyeung

AU - Park, Tae Gwan

PY - 1998/8

Y1 - 1998/8

N2 - A new approach of controlled release of two hydrophilic model drugs, lysozyme and protected tryptophan (Fmoc-Trp(Boc)), from poly(D,L-lactic-co-glycolic acid) [PLGA] microspheres was attempted. The novel formulation strategy is based on the hypothesis that lysozyme can not be released from microspheres until the PLGA polymer chain gradually degrades and reaches to a critical molecular weight at which the water solubility of lysozyme-PLGA oligomer conjugate is sufficiently gained. The drug-PLGA conjugates were formulated into microspheres by a single O/W emulsion method. The drug release kinetic behaviors from the conjugated drug loaded microspheres were compared with those from the conventional unconjugated drug loaded microspheres.

AB - A new approach of controlled release of two hydrophilic model drugs, lysozyme and protected tryptophan (Fmoc-Trp(Boc)), from poly(D,L-lactic-co-glycolic acid) [PLGA] microspheres was attempted. The novel formulation strategy is based on the hypothesis that lysozyme can not be released from microspheres until the PLGA polymer chain gradually degrades and reaches to a critical molecular weight at which the water solubility of lysozyme-PLGA oligomer conjugate is sufficiently gained. The drug-PLGA conjugates were formulated into microspheres by a single O/W emulsion method. The drug release kinetic behaviors from the conjugated drug loaded microspheres were compared with those from the conventional unconjugated drug loaded microspheres.

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M3 - Conference article

AN - SCOPUS:0032136528

SN - 0032-3934

VL - 39

SP - 216

EP - 217

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 2

T2 - Proceedings of the 1997 Boston Meeting

Y2 - 23 August 1998 through 27 August 1998

ER -

Conjugation approach of drug to biodegradable poly(D,L-lactic-CO-glycolic acid) for controlled release from microspheres

Abstract

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