Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins

Allan S. Hoffman; Patrick S. Stayton; Tsuyoshi Shimoboji; Guohua Chen; Zhongli Ding; Ashutosh Chilkoti; Cindi Long; Morikazu Miura; Jingping Chen; Taegwan Park; Nobuo Monji; Carol Ann Cole; J. Milton Harris; K. Nakamae

doi:10.1002/masy.19971180173

Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins

Allan S. Hoffman
, Patrick S. Stayton
, Tsuyoshi Shimoboji
, Guohua Chen
, Zhongli Ding
, Ashutosh Chilkoti
, Cindi Long
, Morikazu Miura
, Jingping Chen
, Taegwan Park
, Nobuo Monji
, Carol Ann Cole
, J. Milton Harris
, K. Nakamae

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.

Original language	English
Pages (from-to)	553-562
Number of pages	10
Journal	Macromolecular Symposia
Volume	118
DOIs	https://doi.org/10.1002/masy.19971180173
State	Published - Jun 1997
Externally published	Yes

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10.1002/masy.19971180173

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Hoffman, A. S., Stayton, P. S., Shimoboji, T., Chen, G., Ding, Z., Chilkoti, A., Long, C., Miura, M., Chen, J., Park, T., Monji, N., Cole, C. A., Harris, J. M., & Nakamae, K. (1997). Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins. Macromolecular Symposia, 118, 553-562. https://doi.org/10.1002/masy.19971180173

@article{314edd152e3d45cfa91007a5b6ebc3e5,

title = "Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins",

abstract = "Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these {"}smart{"} polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.",

author = "Hoffman, \{Allan S.\} and Stayton, \{Patrick S.\} and Tsuyoshi Shimoboji and Guohua Chen and Zhongli Ding and Ashutosh Chilkoti and Cindi Long and Morikazu Miura and Jingping Chen and Taegwan Park and Nobuo Monji and Cole, \{Carol Ann\} and Harris, \{J. Milton\} and K. Nakamae",

year = "1997",

month = jun,

doi = "10.1002/masy.19971180173",

language = "English",

volume = "118",

pages = "553--562",

journal = "Macromolecular Symposia",

issn = "1022-1360",

publisher = "Wiley-VCH Verlag",

}

Hoffman, AS, Stayton, PS, Shimoboji, T, Chen, G, Ding, Z, Chilkoti, A, Long, C, Miura, M, Chen, J, Park, T, Monji, N, Cole, CA, Harris, JM & Nakamae, K 1997, 'Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins', Macromolecular Symposia, vol. 118, pp. 553-562. https://doi.org/10.1002/masy.19971180173

TY - JOUR

T1 - Conjugates of Stimuli-Responsive Polymers and Biomolecules

T2 - Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins

AU - Hoffman, Allan S.

AU - Stayton, Patrick S.

AU - Shimoboji, Tsuyoshi

AU - Chen, Guohua

AU - Ding, Zhongli

AU - Chilkoti, Ashutosh

AU - Long, Cindi

AU - Miura, Morikazu

AU - Chen, Jingping

AU - Park, Taegwan

AU - Monji, Nobuo

AU - Cole, Carol Ann

AU - Harris, J. Milton

AU - Nakamae, K.

PY - 1997/6

Y1 - 1997/6

N2 - Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.

AB - Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.

UR - https://www.scopus.com/pages/publications/0031528744

U2 - 10.1002/masy.19971180173

DO - 10.1002/masy.19971180173

M3 - Article

AN - SCOPUS:0031528744

SN - 1022-1360

VL - 118

SP - 553

EP - 562

JO - Macromolecular Symposia

JF - Macromolecular Symposia

ER -

Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins

Abstract

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