TY - JOUR
T1 - Conjugates of Stimuli-Responsive Polymers and Biomolecules
T2 - Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins
AU - Hoffman, Allan S.
AU - Stayton, Patrick S.
AU - Shimoboji, Tsuyoshi
AU - Chen, Guohua
AU - Ding, Zhongli
AU - Chilkoti, Ashutosh
AU - Long, Cindi
AU - Miura, Morikazu
AU - Chen, Jingping
AU - Park, Taegwan
AU - Monji, Nobuo
AU - Cole, Carol Ann
AU - Harris, J. Milton
AU - Nakamae, K.
PY - 1997/6
Y1 - 1997/6
N2 - Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.
AB - Intelligent polymers exhibit sharp, reversible phase changes in response to small changes in environmental conditions. For example, a small temperature change can cause a sharp precipitation or gelation of a smart polymer solution. Conjugation of these unusual polymers to biomolecules such as enzymes, ligands, lipids, and drugs can lead to many new and exciting applications in medicine and biotechnology. (1-4) This presentation reviews the principles, methodolgies and applications of these "smart" polymer-biomolecule systems, with special focus on temperature-sensitive polymer-protein conjugates.
UR - https://www.scopus.com/pages/publications/0031528744
U2 - 10.1002/masy.19971180173
DO - 10.1002/masy.19971180173
M3 - Article
AN - SCOPUS:0031528744
SN - 1022-1360
VL - 118
SP - 553
EP - 562
JO - Macromolecular Symposia
JF - Macromolecular Symposia
ER -