Concentration-independent spontaneously forming biomimetric vesicles

M. P. Nieh; T. A. Harroun; V. A. Raghunathan; C. J. Glinka; J. Katsaras

doi:10.1103/PhysRevLett.91.158105

Concentration-independent spontaneously forming biomimetric vesicles

M. P. Nieh
, T. A. Harroun
, V. A. Raghunathan
, C. J. Glinka
, J. Katsaras

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge [Formula presented]) or the divalent cation, calcium ([Formula presented]), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.

Original language	English
Journal	Physical Review Letters
Volume	91
Issue number	15
DOIs	https://doi.org/10.1103/PhysRevLett.91.158105
State	Published - 2003
Externally published	Yes

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10.1103/PhysRevLett.91.158105

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title = "Concentration-independent spontaneously forming biomimetric vesicles",

abstract = "In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge [Formula presented]) or the divalent cation, calcium ([Formula presented]), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.",

author = "Nieh, \{M. P.\} and Harroun, \{T. A.\} and Raghunathan, \{V. A.\} and Glinka, \{C. J.\} and J. Katsaras",

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journal = "Physical Review Letters",

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T1 - Concentration-independent spontaneously forming biomimetric vesicles

AU - Nieh, M. P.

AU - Harroun, T. A.

AU - Raghunathan, V. A.

AU - Glinka, C. J.

AU - Katsaras, J.

PY - 2003

Y1 - 2003

N2 - In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge [Formula presented]) or the divalent cation, calcium ([Formula presented]), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.

AB - In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge [Formula presented]) or the divalent cation, calcium ([Formula presented]), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.

UR - https://www.scopus.com/pages/publications/0642285275

U2 - 10.1103/PhysRevLett.91.158105

DO - 10.1103/PhysRevLett.91.158105

M3 - Article

C2 - 14611504

AN - SCOPUS:0642285275

SN - 0031-9007

VL - 91

JO - Physical Review Letters

JF - Physical Review Letters

IS - 15

ER -

Concentration-independent spontaneously forming biomimetric vesicles

Abstract

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