Comparative study on the chiral separation of phenyl alcohols by capillary electrophoresis and liquid chromatography

Yu Ping Zhang; Kwang Pill Lee; Sang Ho Kim; Seong Ho Choi; Anantha I. Gopalan; Zhuo Bin Yuan

doi:10.1002/elps.200405969

Comparative study on the chiral separation of phenyl alcohols by capillary electrophoresis and liquid chromatography

Yu Ping Zhang, Kwang Pill Lee, Sang Ho Kim, Seong Ho Choi, Anantha I. Gopalan, Zhuo Bin Yuan

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Structurally related phenyl alcohols were separated by capillary electrophoresis and liquid chromatography. A statistical experimental design was used in order to optimize the main electrophoretic parameters such as pH, concentration of selector and separation voltage in capillary electrophoresis (CE). Response surfaces were derived using the mathematical model and used for a selection of the optimal experimental conditions. Concentration of the chiral selector, the distance between the aromatic group and asymmetric center of the analytes, were identified as the factors influencing the complexation, selectivity and resolution. Experiments were also performed by high-performance liquid chromatography (HPLC) and the results of CE and HPLC were compared.

Original language	English
Pages (from-to)	2711-2719
Number of pages	9
Journal	Electrophoresis
Volume	25
Issue number	16
DOIs	https://doi.org/10.1002/elps.200405969
State	Published - Aug 2004
Externally published	Yes

Keywords

Capillary electrophoresis
Enantiomer separation
Liquid chromatography
Statistical experimental design
Sulfated β -cyclodextrin

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10.1002/elps.200405969

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abstract = "Structurally related phenyl alcohols were separated by capillary electrophoresis and liquid chromatography. A statistical experimental design was used in order to optimize the main electrophoretic parameters such as pH, concentration of selector and separation voltage in capillary electrophoresis (CE). Response surfaces were derived using the mathematical model and used for a selection of the optimal experimental conditions. Concentration of the chiral selector, the distance between the aromatic group and asymmetric center of the analytes, were identified as the factors influencing the complexation, selectivity and resolution. Experiments were also performed by high-performance liquid chromatography (HPLC) and the results of CE and HPLC were compared.",

keywords = "Capillary electrophoresis, Enantiomer separation, Liquid chromatography, Statistical experimental design, Sulfated β -cyclodextrin",

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AU - Lee, Kwang Pill

AU - Kim, Sang Ho

AU - Choi, Seong Ho

AU - Gopalan, Anantha I.

AU - Yuan, Zhuo Bin

PY - 2004/8

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AB - Structurally related phenyl alcohols were separated by capillary electrophoresis and liquid chromatography. A statistical experimental design was used in order to optimize the main electrophoretic parameters such as pH, concentration of selector and separation voltage in capillary electrophoresis (CE). Response surfaces were derived using the mathematical model and used for a selection of the optimal experimental conditions. Concentration of the chiral selector, the distance between the aromatic group and asymmetric center of the analytes, were identified as the factors influencing the complexation, selectivity and resolution. Experiments were also performed by high-performance liquid chromatography (HPLC) and the results of CE and HPLC were compared.

KW - Capillary electrophoresis

KW - Enantiomer separation

KW - Liquid chromatography

KW - Statistical experimental design

KW - Sulfated β -cyclodextrin

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Comparative study on the chiral separation of phenyl alcohols by capillary electrophoresis and liquid chromatography

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Keywords

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