Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

J. Alfredo Blakeley-Ruiz; Carlee S. McClintock; Ralph Lydic; Helen A. Baghdoyan; James J. Choo; Robert L. Hettich

doi:10.1017/S0140525X18002911

Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

J. Alfredo Blakeley-Ruiz, Carlee S. McClintock, Ralph Lydic, Helen A. Baghdoyan, James J. Choo, Robert L. Hettich

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Abstract

The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology-omics techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

Original language	English
Article number	e66
Journal	Behavioral and Brain Sciences
Volume	42
DOIs	https://doi.org/10.1017/S0140525X18002911
State	Published - Sep 12 2019

Funding

Acknowledgments. KBH and MAO acknowledge support from the French government via the “Investments for the Future” Programme, IdEx Bordeaux (ANR-10-IDEX-03-02). JPK was financially supported in 2018 by the CNRS as part of its “Osez l’interdisciplinarité!” programme. 1. The authors declare no conflict of interest. The financial support for the PhD of Boushra Dalile is supported by an unrestricted grant from Nestec SA. 2. Authors Kristin Verbeke, Lukas Van Oudenhove, and Bram Vervliet contributed equally to this work as senior authors.

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title = "Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research",

abstract = "The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology-omics techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.",

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AU - Lydic, Ralph

AU - Baghdoyan, Helen A.

AU - Choo, James J.

AU - Hettich, Robert L.

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AB - The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology-omics techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

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Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

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