Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

J. Alfredo Blakeley-Ruiz, Carlee S. McClintock, Ralph Lydic, Helen A. Baghdoyan, James J. Choo, Robert L. Hettich

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology-omics techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

Original languageEnglish
Article numbere66
JournalBehavioral and Brain Sciences
Volume42
DOIs
StatePublished - Sep 12 2019

Funding

Acknowledgments. KBH and MAO acknowledge support from the French government via the “Investments for the Future” Programme, IdEx Bordeaux (ANR-10-IDEX-03-02). JPK was financially supported in 2018 by the CNRS as part of its “Osez l’interdisciplinarité!” programme. 1. The authors declare no conflict of interest. The financial support for the PhD of Boushra Dalile is supported by an unrestricted grant from Nestec SA. 2. Authors Kristin Verbeke, Lukas Van Oudenhove, and Bram Vervliet contributed equally to this work as senior authors.

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