Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia

Ki Hyun Bae; Mihyun Park; Min Jae Do; Nohyun Lee; Ji Hyun Ryu; Gun Woo Kim; Cheolgi Kim; Tae Gwan Park; Taeghwan Hyeon

doi:10.1021/nn301046w

Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia

Ki Hyun Bae
, Mihyun Park
, Min Jae Do
, Nohyun Lee
, Ji Hyun Ryu
, Gun Woo Kim
, Cheolgi Kim
, Tae Gwan Park
, Taeghwan Hyeon

Research output: Contribution to journal › Article › peer-review

299 Scopus citations

Abstract

Figure Persented: Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.

Original language	English
Pages (from-to)	5266-5273
Number of pages	8
Journal	ACS Nano
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/nn301046w
State	Published - Jun 26 2012
Externally published	Yes

Keywords

cancer therapy
chitosan
hyperthermia
magnetic modulation
magnetite
nanocube

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10.1021/nn301046w

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title = "Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia",

abstract = "Figure Persented: Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.",

keywords = "cancer therapy, chitosan, hyperthermia, magnetic modulation, magnetite, nanocube",

author = "Bae, \{Ki Hyun\} and Mihyun Park and Do, \{Min Jae\} and Nohyun Lee and Ryu, \{Ji Hyun\} and Kim, \{Gun Woo\} and Cheolgi Kim and Park, \{Tae Gwan\} and Taeghwan Hyeon",

year = "2012",

month = jun,

day = "26",

doi = "10.1021/nn301046w",

language = "English",

volume = "6",

pages = "5266--5273",

journal = "ACS Nano",

issn = "1936-0851",

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TY - JOUR

T1 - Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia

AU - Bae, Ki Hyun

AU - Park, Mihyun

AU - Do, Min Jae

AU - Lee, Nohyun

AU - Ryu, Ji Hyun

AU - Kim, Gun Woo

AU - Kim, Cheolgi

AU - Park, Tae Gwan

AU - Hyeon, Taeghwan

PY - 2012/6/26

Y1 - 2012/6/26

N2 - Figure Persented: Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.

AB - Figure Persented: Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.

KW - cancer therapy

KW - chitosan

KW - hyperthermia

KW - magnetic modulation

KW - magnetite

KW - nanocube

UR - https://www.scopus.com/pages/publications/84862860615

U2 - 10.1021/nn301046w

DO - 10.1021/nn301046w

M3 - Article

C2 - 22588093

AN - SCOPUS:84862860615

SN - 1936-0851

VL - 6

SP - 5266

EP - 5273

JO - ACS Nano

JF - ACS Nano

IS - 6

ER -

Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia

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Keywords

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