Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia

Ki Hyun Bae, Mihyun Park, Min Jae Do, Nohyun Lee, Ji Hyun Ryu, Gun Woo Kim, Cheolgi Kim, Tae Gwan Park, Taeghwan Hyeon

Research output: Contribution to journalArticlepeer-review

286 Scopus citations

Abstract

Figure Persented: Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.

Original languageEnglish
Pages (from-to)5266-5273
Number of pages8
JournalACS Nano
Volume6
Issue number6
DOIs
StatePublished - Jun 26 2012
Externally publishedYes

Keywords

  • cancer therapy
  • chitosan
  • hyperthermia
  • magnetic modulation
  • magnetite
  • nanocube

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