Chemical imaging with desorption electrospray ionization mass spectrometry

Vilmos Kertesz, Gary J. Van Berkel

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

Desorption electrospray ionization mass spectrometry (DESI-MS) is a relatively new ambient surface analysis method. This technique requires little or no sample preparation prior to the actual analysis. Along with other application areas, DESI-MS is used to obtain chemical images of different biomolecules in biological tissue sections. In the case of biological tissue analysis, only preparation of the tissue slices is necessary. Furthermore, the method does not require the use of an ionization matrix preventing the redistribution of analytes prior to the analysis. Chemical images are obtained by monitoring the mass spectrometric signals of compounds while moving the sample relative to the DESI sprayer.

Original languageEnglish
Title of host publicationMass Spectrometry Imaging
Subtitle of host publicationPrinciples and Protocols
EditorsStanislav Rubakhin, Jonathan Sweedler
Pages231-241
Number of pages11
DOIs
StatePublished - 2010

Publication series

NameMethods in Molecular Biology
Volume656
ISSN (Print)1064-3745

Keywords

  • Mass spectrometry imaging
  • desorption electrospray ionization
  • propranolol
  • tissue section
  • whole body

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