Characterization of interactions between and among components of the meiotic silencing by unpaired DNA machinery in Neurospora crassa using bimolecular fluorescence complementation

Nirmala Bardiya, William G. Alexander, Tony D. Perdue, Edward G. Barry, Robert L. Metzenberg, Patricia J. Pukkila, Patrick K.T. Shiu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Bimolecular fluorescence complementation (BiFC) is based on the complementation between two nonfluorescent fragments of the yellow fluorescent protein (YFP) when they are united by interactions between proteins covalently linked to them. We have successfully applied BiFC in Neurospora crassa using two genes involved in meiotic silencing by unpaired DNA (MSUD) and observed macromolecular complex formation involving only SAD-1 proteins, only SAD-2 proteins, and mixtures of SAD-1 and SAD-2 proteins.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalGenetics
Volume178
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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