Abstract
Using small angle neutron diffraction and molecular dynamics simulations we studied the interactions between calcium (Ca2+) or zinc (Zn2+) cations, and oriented gel phase dipalmitoyl-phosphatidylcholine (DPPC) bilayers. For both cations studied at 1:7 divalent metal ion to lipid molar ratio (Me2+:DPPC), bilayer thickness increased. Simulation results helped reveal subtle differences in the effects of the two cations on gel phase membranes.
Original language | English |
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Pages (from-to) | 9-14 |
Number of pages | 6 |
Journal | European Pharmaceutical Journal |
Volume | 64 |
Issue number | 2 |
DOIs | |
State | Published - Nov 27 2017 |
Keywords
- Lipid bilayer
- MD simulations
- Metal ions
- Simulation-To-experiment analysis
- Small angle neutron diffraction