Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials

Ji Hyun Ryu, Yuhan Lee, Won Ho Kong, Taek Gyoung Kim, Tae Gwan Park, Haeshin Lee

Research output: Contribution to journalArticlepeer-review

605 Scopus citations

Abstract

Bioinspired from adhesion behaviors of mussels, injectable and thermosensitive chitosan/Pluronic composite hydrogels were synthesized for tissue adhesives and hemostatic materials. Chitosan conjugated with multiple catechol groups in the backbone was cross-linked with terminally thiolated Pluronic F-127 triblock copolymer to produce temperature-sensitive and adhesive sol-gel transition hydrogels. A blend mixture of the catechol-conjugated chitosan and the thiolated Pluronic F-127 was a viscous solution state at room temperature but became a cross-linked gel state with instantaneous solidification at the body temperature and physiological pH. The adhesive chitosan/Pluronic injectable hydrogels with remnant catechol groups showed strong adhesiveness to soft tissues and mucous layers and also demonstrated superior hemostatic properties. These chitosan/Pluronic hydrogels are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and antibleeding materials.

Original languageEnglish
Pages (from-to)2653-2659
Number of pages7
JournalBiomacromolecules
Volume12
Issue number7
DOIs
StatePublished - Jul 11 2011
Externally publishedYes

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