Catalyst-free process for the synthesis of 5-aryl-2-oxazolidinones via cycloaddition reaction of aziridines and carbon dioxide

Xiao Yong Dou; Liang Nian He; Zhen Zhen Yang; Jing Lun Wang

doi:10.1055/s-0030-1258510

Catalyst-free process for the synthesis of 5-aryl-2-oxazolidinones via cycloaddition reaction of aziridines and carbon dioxide

Xiao Yong Dou, Liang Nian He, Zhen Zhen Yang, Jing Lun Wang

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

A simple approach for facile synthesis of 5-aryl-2-oxazolidinones in excellent regioselectivity from aziridines under compressed CO₂ conditions was developed in the absence of any catalyst and organic solvent. The reaction outcome was found to be tuned by subtly adjusting CO₂ pressure. The adduct formed in situ of aziridine and CO₂ is assumed to act as a catalyst in this reaction, which was also studied by means of in situ FT-IR technique.

Original language	English
Article number	W03310ST
Pages (from-to)	2159-2163
Number of pages	5
Journal	Synlett
Issue number	14
DOIs	https://doi.org/10.1055/s-0030-1258510
State	Published - 2010
Externally published	Yes

Keywords

5-aryl-2-oxazolidinones
aziridine
carbon dioxide
catalyst-free

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10.1055/s-0030-1258510

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abstract = "A simple approach for facile synthesis of 5-aryl-2-oxazolidinones in excellent regioselectivity from aziridines under compressed CO2 conditions was developed in the absence of any catalyst and organic solvent. The reaction outcome was found to be tuned by subtly adjusting CO2 pressure. The adduct formed in situ of aziridine and CO2 is assumed to act as a catalyst in this reaction, which was also studied by means of in situ FT-IR technique.",

keywords = "5-aryl-2-oxazolidinones, aziridine, carbon dioxide, catalyst-free",

author = "Dou, {Xiao Yong} and He, {Liang Nian} and Yang, {Zhen Zhen} and Wang, {Jing Lun}",

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doi = "10.1055/s-0030-1258510",

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AU - Dou, Xiao Yong

AU - He, Liang Nian

AU - Yang, Zhen Zhen

AU - Wang, Jing Lun

PY - 2010

Y1 - 2010

N2 - A simple approach for facile synthesis of 5-aryl-2-oxazolidinones in excellent regioselectivity from aziridines under compressed CO2 conditions was developed in the absence of any catalyst and organic solvent. The reaction outcome was found to be tuned by subtly adjusting CO2 pressure. The adduct formed in situ of aziridine and CO2 is assumed to act as a catalyst in this reaction, which was also studied by means of in situ FT-IR technique.

AB - A simple approach for facile synthesis of 5-aryl-2-oxazolidinones in excellent regioselectivity from aziridines under compressed CO2 conditions was developed in the absence of any catalyst and organic solvent. The reaction outcome was found to be tuned by subtly adjusting CO2 pressure. The adduct formed in situ of aziridine and CO2 is assumed to act as a catalyst in this reaction, which was also studied by means of in situ FT-IR technique.

KW - 5-aryl-2-oxazolidinones

KW - aziridine

KW - carbon dioxide

KW - catalyst-free

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ER -

Catalyst-free process for the synthesis of 5-aryl-2-oxazolidinones via cycloaddition reaction of aziridines and carbon dioxide

Abstract

Keywords

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