Cascade alkylation and deuteration with aryl iodides: Via Pd/norbornene catalysis: An efficient method for the synthesis of congested deuterium-labeled arenes

Lei Guo; Chen Xu; Ding Chuan Wu; Guang Qi Hu; Hong Hai Zhang; Kunlun Hong; Su Chen; Xiang Liu

doi:10.1039/c9cc03988k

Cascade alkylation and deuteration with aryl iodides: Via Pd/norbornene catalysis: An efficient method for the synthesis of congested deuterium-labeled arenes

Lei Guo, Chen Xu, Ding Chuan Wu, Guang Qi Hu, Hong Hai Zhang, Kunlun Hong, Su Chen, Xiang Liu

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.

Original language	English
Pages (from-to)	8567-8570
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	59
DOIs	https://doi.org/10.1039/c9cc03988k
State	Published - 2019
Externally published	Yes

Funding

We thank the National Natural Science Foundation of China (Grant Number 21704041) and the Primary Research Development Plan of Jiangsu Province (BE2016183) for support. Part of the work was conducted at Oak Ridge National Laboratory. We thank Peter V. Bonnesen (Oak Ridge National Laboratory) for assistance with the preparation of the manuscript.

Funders	Funder number
National Natural Science Foundation of China	21704041
National Natural Science Foundation of China
Jiangsu Provincial Key Research and Development Program	BE2016183
Jiangsu Provincial Key Research and Development Program

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10.1039/c9cc03988k

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title = "Cascade alkylation and deuteration with aryl iodides: Via Pd/norbornene catalysis: An efficient method for the synthesis of congested deuterium-labeled arenes",

abstract = "An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.",

author = "Lei Guo and Chen Xu and Wu, {Ding Chuan} and Hu, {Guang Qi} and Zhang, {Hong Hai} and Kunlun Hong and Su Chen and Xiang Liu",

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T2 - Via Pd/norbornene catalysis: An efficient method for the synthesis of congested deuterium-labeled arenes

AU - Guo, Lei

AU - Xu, Chen

AU - Wu, Ding Chuan

AU - Hu, Guang Qi

AU - Zhang, Hong Hai

AU - Hong, Kunlun

AU - Chen, Su

AU - Liu, Xiang

PY - 2019

Y1 - 2019

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AB - An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.

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DO - 10.1039/c9cc03988k

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SN - 1359-7345

VL - 55

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JO - Chemical Communications

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ER -

Cascade alkylation and deuteration with aryl iodides: Via Pd/norbornene catalysis: An efficient method for the synthesis of congested deuterium-labeled arenes

Abstract

Funding

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