Biological Agent Detection and Identification by the Block II Chemical Biological Mass Spectrometer

Wayne H. Griest; Marcus B. Wise; Kevin J. Hart; Stephen A. Lammert; Cyril V. Thompson; Arpad A. Vass

doi:10.1002/fact.1019

Biological Agent Detection and Identification by the Block II Chemical Biological Mass Spectrometer

Wayne H. Griest, Marcus B. Wise, Kevin J. Hart, Stephen A. Lammert, Cyril V. Thompson, Arpad A. Vass

Chemical & Isotopic Mass Spectrometry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The Block II Chemical Biological Mass Spectrometer (CBMS) detects and identifies both chemical and biological warfare agents. Biodetection is based upon respirable particle collection by an opposed-jet virtual impactor, liberation of derivatized biomarkers by thermolysis-methylation and their analysis by direct-sampling ion trap mass spectrometry in the full-scan chemical ionization mode. Results from laboratory and field trials demonstrate the capability of the Block II CBMS for biodetection and identification.

Original language	English
Pages (from-to)	177-184
Number of pages	8
Journal	Field Analytical Chemistry and Technology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1002/fact.1019
State	Published - 2001

Keywords

Biodetection and identification
Biological warfare agents
Fieldable ion trap mass spectrometer
Thermal hydrolysis methylation

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10.1002/fact.1019

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title = "Biological Agent Detection and Identification by the Block II Chemical Biological Mass Spectrometer",

abstract = "The Block II Chemical Biological Mass Spectrometer (CBMS) detects and identifies both chemical and biological warfare agents. Biodetection is based upon respirable particle collection by an opposed-jet virtual impactor, liberation of derivatized biomarkers by thermolysis-methylation and their analysis by direct-sampling ion trap mass spectrometry in the full-scan chemical ionization mode. Results from laboratory and field trials demonstrate the capability of the Block II CBMS for biodetection and identification.",

keywords = "Biodetection and identification, Biological warfare agents, Fieldable ion trap mass spectrometer, Thermal hydrolysis methylation",

author = "Griest, \{Wayne H.\} and Wise, \{Marcus B.\} and Hart, \{Kevin J.\} and Lammert, \{Stephen A.\} and Thompson, \{Cyril V.\} and Vass, \{Arpad A.\}",

year = "2001",

doi = "10.1002/fact.1019",

language = "English",

volume = "5",

pages = "177--184",

journal = "Field Analytical Chemistry and Technology",

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T1 - Biological Agent Detection and Identification by the Block II Chemical Biological Mass Spectrometer

AU - Griest, Wayne H.

AU - Wise, Marcus B.

AU - Hart, Kevin J.

AU - Lammert, Stephen A.

AU - Thompson, Cyril V.

AU - Vass, Arpad A.

PY - 2001

Y1 - 2001

N2 - The Block II Chemical Biological Mass Spectrometer (CBMS) detects and identifies both chemical and biological warfare agents. Biodetection is based upon respirable particle collection by an opposed-jet virtual impactor, liberation of derivatized biomarkers by thermolysis-methylation and their analysis by direct-sampling ion trap mass spectrometry in the full-scan chemical ionization mode. Results from laboratory and field trials demonstrate the capability of the Block II CBMS for biodetection and identification.

AB - The Block II Chemical Biological Mass Spectrometer (CBMS) detects and identifies both chemical and biological warfare agents. Biodetection is based upon respirable particle collection by an opposed-jet virtual impactor, liberation of derivatized biomarkers by thermolysis-methylation and their analysis by direct-sampling ion trap mass spectrometry in the full-scan chemical ionization mode. Results from laboratory and field trials demonstrate the capability of the Block II CBMS for biodetection and identification.

KW - Biodetection and identification

KW - Biological warfare agents

KW - Fieldable ion trap mass spectrometer

KW - Thermal hydrolysis methylation

UR - https://www.scopus.com/pages/publications/0035601275

U2 - 10.1002/fact.1019

DO - 10.1002/fact.1019

M3 - Article

AN - SCOPUS:0035601275

SN - 1086-900X

VL - 5

SP - 177

EP - 184

JO - Field Analytical Chemistry and Technology

JF - Field Analytical Chemistry and Technology

IS - 4

ER -

Biological Agent Detection and Identification by the Block II Chemical Biological Mass Spectrometer

Abstract

Keywords

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