Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

Yuhan Lee; Haeshin Lee; Young Beom Kim; Jaeyoon Kim; Taeghwan Hyeon; Hyunwook Park; Phillip B. Messersmith; Tae Gwan Park

doi:10.1002/adma.200800756

Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

Yuhan Lee
, Haeshin Lee
, Young Beom Kim
, Jaeyoon Kim
, Taeghwan Hyeon
, Hyunwook Park
, Phillip B. Messersmith
, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

318 Scopus citations

Abstract

A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.

Original language	English
Pages (from-to)	4154-4157
Number of pages	4
Journal	Advanced Materials
Volume	20
Issue number	21
DOIs	https://doi.org/10.1002/adma.200800756
State	Published - Nov 3 2008
Externally published	Yes

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@article{a2ae857df2684419afa94e51ef2a5a2a,

title = "Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging",

abstract = "A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.",

author = "Yuhan Lee and Haeshin Lee and Kim, \{Young Beom\} and Jaeyoon Kim and Taeghwan Hyeon and Hyunwook Park and Messersmith, \{Phillip B.\} and Park, \{Tae Gwan\}",

year = "2008",

month = nov,

day = "3",

doi = "10.1002/adma.200800756",

language = "English",

volume = "20",

pages = "4154--4157",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "wiley",

number = "21",

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TY - JOUR

T1 - Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

AU - Lee, Yuhan

AU - Lee, Haeshin

AU - Kim, Young Beom

AU - Kim, Jaeyoon

AU - Hyeon, Taeghwan

AU - Park, Hyunwook

AU - Messersmith, Phillip B.

AU - Park, Tae Gwan

PY - 2008/11/3

Y1 - 2008/11/3

N2 - A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.

AB - A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.

UR - https://www.scopus.com/pages/publications/55749086601

U2 - 10.1002/adma.200800756

DO - 10.1002/adma.200800756

M3 - Article

AN - SCOPUS:55749086601

SN - 0935-9648

VL - 20

SP - 4154

EP - 4157

JO - Advanced Materials

JF - Advanced Materials

IS - 21

ER -

Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

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