Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

Yuhan Lee; Haeshin Lee; Young Beom Kim; Jaeyoon Kim; Taeghwan Hyeon; Hyunwook Park; Phillip B. Messersmith; Tae Gwan Park

doi:10.1002/adma.200800756

Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

Yuhan Lee, Haeshin Lee, Young Beom Kim, Jaeyoon Kim, Taeghwan Hyeon, Hyunwook Park, Phillip B. Messersmith, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

310 Scopus citations

Abstract

A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.

Original language	English
Pages (from-to)	4154-4157
Number of pages	4
Journal	Advanced Materials
Volume	20
Issue number	21
DOIs	https://doi.org/10.1002/adma.200800756
State	Published - Nov 3 2008
Externally published	Yes

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title = "Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging",

abstract = "A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.",

author = "Yuhan Lee and Haeshin Lee and Kim, {Young Beom} and Jaeyoon Kim and Taeghwan Hyeon and Hyunwook Park and Messersmith, {Phillip B.} and Park, {Tae Gwan}",

year = "2008",

month = nov,

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doi = "10.1002/adma.200800756",

language = "English",

volume = "20",

pages = "4154--4157",

journal = "Advanced Materials",

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T1 - Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

AU - Lee, Yuhan

AU - Lee, Haeshin

AU - Kim, Young Beom

AU - Kim, Jaeyoon

AU - Hyeon, Taeghwan

AU - Park, Hyunwook

AU - Messersmith, Phillip B.

AU - Park, Tae Gwan

PY - 2008/11/3

Y1 - 2008/11/3

N2 - A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.

AB - A mussel-inspired method for homogeneous and robust coating of hyaluronic acid (HA) on monodisperse magnetite nanocrystals in aqueous solution with a cancer targeting capability through CD44-HA receptor-ligand interactions was reported. HA-dopamine conjugates (HA-DN) were prepared using conventional 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC)/1-hydoxybenzotriazole (HOBT) chemistry in pH 5.5 solution to avoid irreversible oxidation of dopamine. The homogeneous coating with HA-DN was achieved by adding a solution of nanocrystals into the HA-DN solution with vortexing for 1 minute. Atomic Force Microscopy images demonstrated homogeneous coating of HA-DN on the surface of the magnetite nanocrystals. High-resolution x-ray photoelectron spectra confirmed the presence of HA-DN, the binding energy of the quaternary nitrogen in CTAB was different from that of nitrogens in N-acetyl and amide groups in HA-DN.

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U2 - 10.1002/adma.200800756

DO - 10.1002/adma.200800756

M3 - Article

AN - SCOPUS:55749086601

SN - 0935-9648

VL - 20

SP - 4154

EP - 4157

JO - Advanced Materials

JF - Advanced Materials

IS - 21

ER -

Bioinspired surface immobilization of hyaluronic acid on monodisperse magnetite nanocrystals for targeted cancer imaging

Abstract

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