Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy

Ana Barra; Zélia Alves; Nuno M. Ferreira; Manuel A. Martins; Helena Oliveira; Liliana P. Ferreira; M. Margarida Cruz; Maria De Deus Carvalho; Sabine M. Neumayer; Brian J. Rodriguez; Cláudia Nunes; Paula Ferreira

doi:10.1039/c9tb02067e

Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy

Ana Barra, Zélia Alves, Nuno M. Ferreira, Manuel A. Martins, Helena Oliveira, Liliana P. Ferreira, M. Margarida Cruz, Maria De Deus Carvalho, Sabine M. Neumayer, Brian J. Rodriguez, Cláudia Nunes, Paula Ferreira

Functional Atomic Force Microscopy Group

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications. Here, the development of flexible and multifunctional chitosan-based bionanocomposites with a mixed reduced graphene oxide-iron oxide (rGO-Fe_3-xO₄) filler is described. The filler is prepared by one-pot synthesis, ensuring good dispersibility of the Fe_3-xO₄ nanoparticles and rGO within the chitosan matrix during solvent casting. The resulting bionanocomposites present superparamagnetic response at room temperature. The antioxidant activity is 9 times higher than that of pristine chitosan. The mechanical properties of the films can be tuned from elastic (∼8 MPa) chitosan films to stiff (∼285 MPa) bionanocomposite films with 50% filler. The magnetic hyperthermia tests showed a temperature increase of 40 °C in 45 s for the 50% rGO-Fe_3-xO₄ film. Furthermore, the composites have no cytotoxicity to the nontumorigenic (HaCat) cell line, which confirms their biocompatibility and highlights the potential of these materials for biomedical applications, such as hyperthermia treatments.

Original language	English
Pages (from-to)	1256-1265
Number of pages	10
Journal	Journal of Materials Chemistry B
Volume	8
Issue number	6
DOIs	https://doi.org/10.1039/c9tb02067e
State	Published - Feb 14 2020

Funding

This work was developed within the scope of the projects: CICECO-Aveiro Institute of Materials, (FCT Ref. UIDB/50011/ 2020 and UIDP/50011/2020); CESAM (FCT Ref. UID/AMB/50017/ 2019); BioISI (FCT Ref. UID/MULTI/04046/2019); CQB (FCT Ref. UID/MULTI/00612/2013); and I3N (FCT Ref. UID/CTM/50025/ 2019) financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. The project M-ERA-NET2/0021/2016 – BIOFOODPACK – Biocomposite Packaging for Active Preservation of Food is acknowledged for funding. ZA, NMF, HO and PF thank FCT for the grants (PD/BD/117457/2016, SFRH/BPD/ 111460/2015, CEECIND/04050/2017 and IF/00300/2015, respectively). CN is funded by national funds (OE), through FCT – Fundação para a Ciência e a Tecnologia, I. P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. SMN and BJR acknowledge the support of Science Foundation Ireland (16/IA/4584, 14/US/I3113 and 07/IN1/B931). This research was partially supported by COST action 15107, Grant No. 101016-080937.

Funders	Funder number
CICECO-Aveiro Institute of Materials
FCT/MEC
Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro	UID/MULTI/00612/2013, UID/AMB/50017/ 2019, UID/MULTI/04046/2019, UID/CTM/50025/ 2019
Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro
European Cooperation in Science and Technology	101016-080937, 15107
European Cooperation in Science and Technology
Science Foundation Ireland	07/IN1/B931, 14/US/I3113, 16/IA/4584
Science Foundation Ireland
Fundação para a Ciência e a Tecnologia	UIDP/50011/2020, UIDB/50011/ 2020
Fundação para a Ciência e a Tecnologia
Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção
European Regional Development Fund	IF/00300/2015, M-ERA-NET2/0021/2016, CEECIND/04050/2017, SFRH/BPD/ 111460/2015, PD/BD/117457/2016
European Regional Development Fund

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title = "Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy",

abstract = "Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications. Here, the development of flexible and multifunctional chitosan-based bionanocomposites with a mixed reduced graphene oxide-iron oxide (rGO-Fe3-xO4) filler is described. The filler is prepared by one-pot synthesis, ensuring good dispersibility of the Fe3-xO4 nanoparticles and rGO within the chitosan matrix during solvent casting. The resulting bionanocomposites present superparamagnetic response at room temperature. The antioxidant activity is 9 times higher than that of pristine chitosan. The mechanical properties of the films can be tuned from elastic (∼8 MPa) chitosan films to stiff (∼285 MPa) bionanocomposite films with 50% filler. The magnetic hyperthermia tests showed a temperature increase of 40 °C in 45 s for the 50% rGO-Fe3-xO4 film. Furthermore, the composites have no cytotoxicity to the nontumorigenic (HaCat) cell line, which confirms their biocompatibility and highlights the potential of these materials for biomedical applications, such as hyperthermia treatments.",

author = "Ana Barra and Z{\'e}lia Alves and Ferreira, {Nuno M.} and Martins, {Manuel A.} and Helena Oliveira and Ferreira, {Liliana P.} and Cruz, {M. Margarida} and Carvalho, {Maria De Deus} and Neumayer, {Sabine M.} and Rodriguez, {Brian J.} and Cl{\'a}udia Nunes and Paula Ferreira",

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AU - Barra, Ana

AU - Alves, Zélia

AU - Ferreira, Nuno M.

AU - Martins, Manuel A.

AU - Oliveira, Helena

AU - Ferreira, Liliana P.

AU - Cruz, M. Margarida

AU - Carvalho, Maria De Deus

AU - Neumayer, Sabine M.

AU - Rodriguez, Brian J.

AU - Nunes, Cláudia

AU - Ferreira, Paula

PY - 2020/2/14

Y1 - 2020/2/14

N2 - Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications. Here, the development of flexible and multifunctional chitosan-based bionanocomposites with a mixed reduced graphene oxide-iron oxide (rGO-Fe3-xO4) filler is described. The filler is prepared by one-pot synthesis, ensuring good dispersibility of the Fe3-xO4 nanoparticles and rGO within the chitosan matrix during solvent casting. The resulting bionanocomposites present superparamagnetic response at room temperature. The antioxidant activity is 9 times higher than that of pristine chitosan. The mechanical properties of the films can be tuned from elastic (∼8 MPa) chitosan films to stiff (∼285 MPa) bionanocomposite films with 50% filler. The magnetic hyperthermia tests showed a temperature increase of 40 °C in 45 s for the 50% rGO-Fe3-xO4 film. Furthermore, the composites have no cytotoxicity to the nontumorigenic (HaCat) cell line, which confirms their biocompatibility and highlights the potential of these materials for biomedical applications, such as hyperthermia treatments.

AB - Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications. Here, the development of flexible and multifunctional chitosan-based bionanocomposites with a mixed reduced graphene oxide-iron oxide (rGO-Fe3-xO4) filler is described. The filler is prepared by one-pot synthesis, ensuring good dispersibility of the Fe3-xO4 nanoparticles and rGO within the chitosan matrix during solvent casting. The resulting bionanocomposites present superparamagnetic response at room temperature. The antioxidant activity is 9 times higher than that of pristine chitosan. The mechanical properties of the films can be tuned from elastic (∼8 MPa) chitosan films to stiff (∼285 MPa) bionanocomposite films with 50% filler. The magnetic hyperthermia tests showed a temperature increase of 40 °C in 45 s for the 50% rGO-Fe3-xO4 film. Furthermore, the composites have no cytotoxicity to the nontumorigenic (HaCat) cell line, which confirms their biocompatibility and highlights the potential of these materials for biomedical applications, such as hyperthermia treatments.

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Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy

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