Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Shih Jie Lin; Jia An Lin; Wei Yu; Chanho Lee; Chun Yu Hung; Jonathan D. Poplawsky; Peter K. Liaw; Yi Chia Chou

doi:10.1021/acsabm.1c01103

Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

Shih Jie Lin, Jia An Lin, Wei Yu, Chanho Lee, Chun Yu Hung, Jonathan D. Poplawsky, Peter K. Liaw, Yi Chia Chou

Materials MicroAnalysis

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.

Original language	English
Pages (from-to)	642-649
Number of pages	8
Journal	ACS Applied Bio Materials
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/acsabm.1c01103
State	Published - Feb 21 2022

Funding

We acknowledge funding from the Ministry of Science and Technology of Taiwan under Grant No. MOST-110-2636-M-009-008 (Young Scholar Fellowship Program) and Chang Gung Medical Foundation under Grant No. CMRPG3J1131 and CMRPVVK0141 (Biomedical Application Research of Novel High Entropy Alloy NbTaTiVZr). We also acknowledge the core facility support in National Yang Ming Chiao Tung University (NYCU) from MOST. The present work was partially supported by the “High-Entropy Materials Center” from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. C.H.L. and P.K.L. very much appreciate supports from the National Science Foundation (DMR-1611180 and 1809640) with program directors Drs. J. Yang, G. Shiflet, and D. Farkas and the US Army Research Office (W911NF-13-1-0438 and W911NF-19-2-0049) with program managers Drs. M. P. Bakas, S. N. Mathaudhu, and D. M. Stepp. APT was conducted at ORNL’s Center for Nanophase Materials Sciences (CNMS), which is a U.S. DOE Office of Science User Facility with proposal number CNMS2015-312 and run number R29-13561.

Keywords

NbTaTiVZr
biocompatibility
biomedical material
in vitro test
surface modification

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10.1021/acsabm.1c01103

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title = "Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts",

abstract = "We report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.",

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AU - Lin, Shih Jie

AU - Lin, Jia An

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AU - Lee, Chanho

AU - Hung, Chun Yu

AU - Poplawsky, Jonathan D.

AU - Liaw, Peter K.

AU - Chou, Yi Chia

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AB - We report a potential biomedical material, NbTaTiVZr, and the impact of surface roughness on the osteoblast culture and later behavior based on in vitro tests of preosteoblasts. Cell activities such as adhesion, viability, and typical protein activity on NbTaTiVZr showed comparable results with that of commercially pure Ti (CP-Ti). In addition, NbTaTiVZr with a smooth surface exhibits better cell adhesion, viability, and typical protein activity which shows that surface modification can improve the biocompatibility of NbTaTiVZr. This supports the biological evidence and shows that NbTaTiVZr can potentially be evaluated as a biomedical material for clinical use.

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Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

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