TY - JOUR
T1 - Bimodal fluorescence and magnetic resonance imaging using water-soluble hexagonal NaYF 4:Ce,Tb,Gd nanocrystals
AU - Ren, Wen Ting
AU - Liang, Liang Bo
AU - Qi, Fei
AU - Sun, Zheng Bo
AU - Yang, Zhi Yong
AU - Huang, Xiao Qi
AU - Wu, Qi Zhu
AU - Zhu, Hong Yan
AU - Yu, Xue Feng
AU - Quan, Hong
AU - Gong, Qi Yong
PY - 2011
Y1 - 2011
N2 - The present study explored the feasibility of using hexagonal-phase NaYF 4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF 4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26), and decent MR T 1 relaxivity (r 1 = 2.87 mM 1s 1). The NaYF 4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF 4:Ce,Tb,Gd NCs also significantly increased T 1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF 4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.
AB - The present study explored the feasibility of using hexagonal-phase NaYF 4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF 4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26), and decent MR T 1 relaxivity (r 1 = 2.87 mM 1s 1). The NaYF 4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF 4:Ce,Tb,Gd NCs also significantly increased T 1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF 4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.
UR - https://www.scopus.com/pages/publications/84862927032
U2 - 10.1155/2011/531217
DO - 10.1155/2011/531217
M3 - Article
AN - SCOPUS:84862927032
SN - 1687-4110
VL - 2011
JO - Journal of Nanomaterials
JF - Journal of Nanomaterials
M1 - 531217
ER -