Bimodal fluorescence and magnetic resonance imaging using water-soluble hexagonal NaYF 4:Ce,Tb,Gd nanocrystals

Wen Ting Ren; Liang Bo Liang; Fei Qi; Zheng Bo Sun; Zhi Yong Yang; Xiao Qi Huang; Qi Zhu Wu; Hong Yan Zhu; Xue Feng Yu; Hong Quan; Qi Yong Gong

doi:10.1155/2011/531217

Bimodal fluorescence and magnetic resonance imaging using water-soluble hexagonal NaYF ₄:Ce,Tb,Gd nanocrystals

Wen Ting Ren
, Liang Bo Liang
, Fei Qi
, Zheng Bo Sun
, Zhi Yong Yang
, Xiao Qi Huang
, Qi Zhu Wu
, Hong Yan Zhu
, Xue Feng Yu
, Hong Quan
, Qi Yong Gong

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The present study explored the feasibility of using hexagonal-phase NaYF ₄:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF ₄:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26), and decent MR T 1 relaxivity (r ₁ = 2.87 mM ₁s ₁). The NaYF ₄:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF ₄:Ce,Tb,Gd NCs also significantly increased T ₁ signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF ₄:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.

Original language	English
Article number	531217
Journal	Journal of Nanomaterials
Volume	2011
DOIs	https://doi.org/10.1155/2011/531217
State	Published - 2011
Externally published	Yes

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@article{a275600e2b2f4e56922a0ccc525459a1,

title = "Bimodal fluorescence and magnetic resonance imaging using water-soluble hexagonal NaYF 4:Ce,Tb,Gd nanocrystals",

abstract = "The present study explored the feasibility of using hexagonal-phase NaYF 4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF 4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26), and decent MR T 1 relaxivity (r 1 = 2.87 mM 1s 1). The NaYF 4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF 4:Ce,Tb,Gd NCs also significantly increased T 1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF 4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.",

author = "Ren, \{Wen Ting\} and Liang, \{Liang Bo\} and Fei Qi and Sun, \{Zheng Bo\} and Yang, \{Zhi Yong\} and Huang, \{Xiao Qi\} and Wu, \{Qi Zhu\} and Zhu, \{Hong Yan\} and Yu, \{Xue Feng\} and Hong Quan and Gong, \{Qi Yong\}",

year = "2011",

doi = "10.1155/2011/531217",

language = "English",

volume = "2011",

journal = "Journal of Nanomaterials",

issn = "1687-4110",

publisher = "Hindawi",

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TY - JOUR

T1 - Bimodal fluorescence and magnetic resonance imaging using water-soluble hexagonal NaYF 4:Ce,Tb,Gd nanocrystals

AU - Ren, Wen Ting

AU - Liang, Liang Bo

AU - Qi, Fei

AU - Sun, Zheng Bo

AU - Yang, Zhi Yong

AU - Huang, Xiao Qi

AU - Wu, Qi Zhu

AU - Zhu, Hong Yan

AU - Yu, Xue Feng

AU - Quan, Hong

AU - Gong, Qi Yong

PY - 2011

Y1 - 2011

N2 - The present study explored the feasibility of using hexagonal-phase NaYF 4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF 4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26), and decent MR T 1 relaxivity (r 1 = 2.87 mM 1s 1). The NaYF 4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF 4:Ce,Tb,Gd NCs also significantly increased T 1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF 4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.

AB - The present study explored the feasibility of using hexagonal-phase NaYF 4:Ce,Tb,Gd nanocrystals as bimodal probes for fluorescence and magnetic resonance (MR) imaging. Using a facile and user-friendly strategy, the NaYF 4:Ce,Tb,Gd nanocrystals were synthesized with good water dispensability, high quantum yield (26), and decent MR T 1 relaxivity (r 1 = 2.87 mM 1s 1). The NaYF 4:Ce,Tb,Gd NCs conjugated by folic acid presented great efficiency in fluorescence imaging of C6 glioma cells in vitro. Meanwhile, in in vivo MR experiments on rats, the NaYF 4:Ce,Tb,Gd NCs also significantly increased T 1 signal in the liver, spleen, and kidney even with a low probe dose. The proposed NaYF 4:Ce,Tb,Gd nanoprobes hold promise for simultaneous bimodal fluorescence and MR bioimaging.

UR - https://www.scopus.com/pages/publications/84862927032

U2 - 10.1155/2011/531217

DO - 10.1155/2011/531217

M3 - Article

AN - SCOPUS:84862927032

SN - 1687-4110

VL - 2011

JO - Journal of Nanomaterials

JF - Journal of Nanomaterials

M1 - 531217

ER -

Bimodal fluorescence and magnetic resonance imaging using water-soluble hexagonal NaYF ₄:Ce,Tb,Gd nanocrystals

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