"Bicellar" lipid mixtures as used in biochemical and biophysical studies

John Katsaras, Thad A. Harroun, Jeremy Pencer, Mu Ping Nieh

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations

Abstract

Over the past decade "bicellar" lipid mixtures composed of the long-chain dimyristoyl phosphatidylcholine (DMPC) and the short-chain dihexanoyl PC (DHPC) molecules have emerged as a powerful medium for studying membrane associated, biologically relevant macromolecules and assemblies. Depending on temperature, lipid concentration and composition these lipid mixtures can assume a variety of morphologies, some of them alignable in the presence of a magnetic field. This article will examine the biophysical studies that have elucidated the various morphologies assumed by these lipid mixtures, and their use in the biochemical studies of biomolecules.

Original languageEnglish
Pages (from-to)355-366
Number of pages12
JournalNaturwissenschaften
Volume92
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

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