Beryllium displacement of H+ from strong hydrogen bonds

T. Mark McCleskey; Deborah S. Ehler; Timothy S. Keizer; Dilip N. Asthagiri; Lawrence R. Pratt; Ryszard Michalczyk; Brian L. Scott

doi:10.1002/anie.200604623

Beryllium displacement of H⁺ from strong hydrogen bonds

T. Mark McCleskey, Deborah S. Ehler, Timothy S. Keizer, Dilip N. Asthagiri, Lawrence R. Pratt, Ryszard Michalczyk, Brian L. Scott

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H⁺ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a "tetrahedral proton" is thermodynamically preferred, provides insight into the transport mechanism of beryllium in chronic beryllium disease. (Chemical Equation Presented).

Original language	English
Pages (from-to)	2669-2671
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	15
DOIs	https://doi.org/10.1002/anie.200604623
State	Published - 2007
Externally published	Yes

Keywords

Beryllium
Bioinorganic chemistry
Hydrogen bonds
Metalloproteins

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10.1002/anie.200604623

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title = "Beryllium displacement of H+ from strong hydrogen bonds",

abstract = "It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H+ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a {"}tetrahedral proton{"} is thermodynamically preferred, provides insight into the transport mechanism of beryllium in chronic beryllium disease. (Chemical Equation Presented).",

keywords = "Beryllium, Bioinorganic chemistry, Hydrogen bonds, Metalloproteins",

author = "McCleskey, \{T. Mark\} and Ehler, \{Deborah S.\} and Keizer, \{Timothy S.\} and Asthagiri, \{Dilip N.\} and Pratt, \{Lawrence R.\} and Ryszard Michalczyk and Scott, \{Brian L.\}",

year = "2007",

doi = "10.1002/anie.200604623",

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T1 - Beryllium displacement of H+ from strong hydrogen bonds

AU - McCleskey, T. Mark

AU - Ehler, Deborah S.

AU - Keizer, Timothy S.

AU - Asthagiri, Dilip N.

AU - Pratt, Lawrence R.

AU - Michalczyk, Ryszard

AU - Scott, Brian L.

PY - 2007

Y1 - 2007

N2 - It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H+ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a "tetrahedral proton" is thermodynamically preferred, provides insight into the transport mechanism of beryllium in chronic beryllium disease. (Chemical Equation Presented).

AB - It's bound to Be: The binding of beryllium to the iron transport protein transferrin proceeds by displacement of H+ from strong hydrogen bonds in the protein (see picture). This new view of beryllium binding, in which beryllium as a "tetrahedral proton" is thermodynamically preferred, provides insight into the transport mechanism of beryllium in chronic beryllium disease. (Chemical Equation Presented).

KW - Beryllium

KW - Bioinorganic chemistry

KW - Hydrogen bonds

KW - Metalloproteins

UR - https://www.scopus.com/pages/publications/34250840025

U2 - 10.1002/anie.200604623

DO - 10.1002/anie.200604623

M3 - Article

C2 - 17348063

AN - SCOPUS:34250840025

SN - 1433-7851

VL - 46

SP - 2669

EP - 2671

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 15

ER -

Beryllium displacement of H⁺ from strong hydrogen bonds

Abstract

Keywords

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