Atmospheric Pressure Drift Tube Ion Mobility-Orbitrap Mass Spectrometry: Initial Performance Characterization

Joel D. Keelor, Stephen Zambrzycki, Anyin Li, Brian H. Clowers, Facundo M. Fernández

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Atmospheric pressure drift tube ion mobility spectrometry (AP-DTIMS) was coupled with Fourier transform Orbitrap mass spectrometry. The performance capabilities of this versatile new arrangement were demonstrated for different DTIMS ion gating operation modes and Orbitrap mass spectrometer parameters with regard to sensitivity and resolving power. Showcasing the optimized AP-DTIMS-Orbitrap MS system, isobaric peptide and sugar isomers were successfully resolved and the identities of separated species validated by high-energy collision dissociation experiments.

Original languageEnglish
Pages (from-to)11301-11309
Number of pages9
JournalAnalytical Chemistry
Volume89
Issue number21
DOIs
StatePublished - Nov 7 2017
Externally publishedYes

Funding

This work was supported by the National Science Foundation and the NASA Astrobiology Program under the NSF Center for Chemical Evolution (Grant CHE-1504217).

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