Assessment of a host-guest interaction in a bilayer membrane model

Harshita Kumari; Saeedeh Negin; Andrew Eisenhart; Mohit B. Patel; Thomas L. Beck; Frank Heinrich; Helena J. Spikes; George W. Gokel

doi:10.1039/d2ra03851j

Assessment of a host-guest interaction in a bilayer membrane model

Harshita Kumari, Saeedeh Negin, Andrew Eisenhart, Mohit B. Patel, Thomas L. Beck, Frank Heinrich, Helena J. Spikes, George W. Gokel

National Center for Computational Scienc

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Supramolecular interactions are well recognized and many of them have been extensively studied in chemistry. The formation of supramolecular complexes that rely on weak force interactions are less well studied in bilayer membranes. Herein, a supported bilayer membrane is used to probe the penetration of a complex between tetracycline and a macrocyclic polyether. In a number of bacterial systems, the presence of the macrocycle has been found to significantly enhance the potency of the antimicrobial in vitro. The crown·tetracycline complex has been characterized in solution, neutron reflectometry has probed complex penetration, and the phenomena have been modeled by computational methods.

Original language	English
Pages (from-to)	32046-32055
Number of pages	10
Journal	RSC Advances
Volume	12
Issue number	49
DOIs	https://doi.org/10.1039/d2ra03851j
State	Published - Nov 10 2022

Funding

GWG thanks the NSF for a grant (NSF: CHE 1710549) and TLB acknowledges financial support from NSF (NSF: CHE 1955161) and from the NIH MBArC program that supported portions of this work. HK thanks UC (start-up funds). FH acknowledges support from the U.S. Department of Commerce (Award 70NANB17H299). We thank Prof. Jerry L. Atwood for his initial support of this work. Research was performed in part at the National Institute of Standards and Technology (NIST) Center for Nanoscale Science and Technology. Certain commercial materials, equipment and instruments are identified in this work to describe the experimental procedure as completely as possible. In no case does such an identification imply a recommendation or endorsement by NIST, nor does it imply that the materials, equipment, or instrument identified are necessarily the best available for the purpose.

Funders	Funder number
National Science Foundation	CHE 1955161, CHE 1710549
National Institutes of Health
National Institute of Standards and Technology
U.S. Department of Commerce	70NANB17H299
University of California

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title = "Assessment of a host-guest interaction in a bilayer membrane model",

abstract = "Supramolecular interactions are well recognized and many of them have been extensively studied in chemistry. The formation of supramolecular complexes that rely on weak force interactions are less well studied in bilayer membranes. Herein, a supported bilayer membrane is used to probe the penetration of a complex between tetracycline and a macrocyclic polyether. In a number of bacterial systems, the presence of the macrocycle has been found to significantly enhance the potency of the antimicrobial in vitro. The crown·tetracycline complex has been characterized in solution, neutron reflectometry has probed complex penetration, and the phenomena have been modeled by computational methods.",

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AU - Heinrich, Frank

AU - Spikes, Helena J.

AU - Gokel, George W.

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Assessment of a host-guest interaction in a bilayer membrane model

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