Approximate volumetric system models for MicroSPECT

J. Gregor; T. Benson; S. Gleason; M. Paulus; S. Figueroa; T. Hoffman; S. Kennel; J. Wall

doi:10.1109/TNS.2006.882774

Approximate volumetric system models for MicroSPECT

J. Gregor, T. Benson, S. Gleason, M. Paulus, S. Figueroa, T. Hoffman, S. Kennel, J. Wall

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A microSPECT system has been developed for the purpose of studying murine models of amyloidosis in vivo. The system is equipped with two detector heads, each consisting of a multi-anode photomultiplier tube coupled to a pixellated NaI(Tl) crystal array. Images are reconstructed using an OS-EM algorithm. In this paper, we describe the associated volumetric system models that we have developed in support of both pinhole and parallel hole collimation. These models, which are precomputed and stored to disk prior to reconstruction, are based on simple inner-product computations and a region-growing like search defined by the conic view that each detector pixel has of the image voxels. We provide illustrative experimental results based on phantom and mouse data.

Original language	English
Article number	1710250
Pages (from-to)	2646-2652
Number of pages	7
Journal	IEEE Transactions on Nuclear Science
Volume	53
Issue number	5
DOIs	https://doi.org/10.1109/TNS.2006.882774
State	Published - Oct 2006

Funding

Manuscript received November 12, 2004; revised July 7, 2005. This work was supported by the NIH under Grant R01 EB00789 and the DHHS under Grants R01-CA72942 and 1P50-CA13013. The computer equipment was acquired as part of SInRG, a University of Tennessee grid infrastructure Grant supported by the NSF under Grant EIA-9972889.

Keywords

Amyloid
Bone scan
Image reconstruction
Single photon emission computed tomography
Small animal imaging
System model

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10.1109/TNS.2006.882774

Cite this

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AU - Benson, T.

AU - Gleason, S.

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AU - Hoffman, T.

AU - Kennel, S.

AU - Wall, J.

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AB - A microSPECT system has been developed for the purpose of studying murine models of amyloidosis in vivo. The system is equipped with two detector heads, each consisting of a multi-anode photomultiplier tube coupled to a pixellated NaI(Tl) crystal array. Images are reconstructed using an OS-EM algorithm. In this paper, we describe the associated volumetric system models that we have developed in support of both pinhole and parallel hole collimation. These models, which are precomputed and stored to disk prior to reconstruction, are based on simple inner-product computations and a region-growing like search defined by the conic view that each detector pixel has of the image voxels. We provide illustrative experimental results based on phantom and mouse data.

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Approximate volumetric system models for MicroSPECT

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