Approximate volumetric system models for MicroSPECT

J. Gregor; T. Benson; S. Gleason; M. Paulus; S. Figueroa; T. Hoffman; S. Kennel; J. Wall

doi:10.1109/TNS.2006.882774

Approximate volumetric system models for MicroSPECT

J. Gregor, T. Benson, S. Gleason, M. Paulus, S. Figueroa, T. Hoffman, S. Kennel, J. Wall

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A microSPECT system has been developed for the purpose of studying murine models of amyloidosis in vivo. The system is equipped with two detector heads, each consisting of a multi-anode photomultiplier tube coupled to a pixellated NaI(Tl) crystal array. Images are reconstructed using an OS-EM algorithm. In this paper, we describe the associated volumetric system models that we have developed in support of both pinhole and parallel hole collimation. These models, which are precomputed and stored to disk prior to reconstruction, are based on simple inner-product computations and a region-growing like search defined by the conic view that each detector pixel has of the image voxels. We provide illustrative experimental results based on phantom and mouse data.

Original language	English
Article number	1710250
Pages (from-to)	2646-2652
Number of pages	7
Journal	IEEE Transactions on Nuclear Science
Volume	53
Issue number	5
DOIs	https://doi.org/10.1109/TNS.2006.882774
State	Published - Oct 2006

Funding

Manuscript received November 12, 2004; revised July 7, 2005. This work was supported by the NIH under Grant R01 EB00789 and the DHHS under Grants R01-CA72942 and 1P50-CA13013. The computer equipment was acquired as part of SInRG, a University of Tennessee grid infrastructure Grant supported by the NSF under Grant EIA-9972889.

Funders	Funder number
National Science Foundation	EIA-9972889
National Institutes of Health	R01 EB00789
U.S. Department of Health and Human Services	1P50-CA13013, R01-CA72942
University of Tennessee

Keywords

Amyloid
Bone scan
Image reconstruction
Single photon emission computed tomography
Small animal imaging
System model

Access to Document

10.1109/TNS.2006.882774

Cite this

@article{b1c1fdd7ea554d7f9786df47cd7598e1,

title = "Approximate volumetric system models for MicroSPECT",

abstract = "A microSPECT system has been developed for the purpose of studying murine models of amyloidosis in vivo. The system is equipped with two detector heads, each consisting of a multi-anode photomultiplier tube coupled to a pixellated NaI(Tl) crystal array. Images are reconstructed using an OS-EM algorithm. In this paper, we describe the associated volumetric system models that we have developed in support of both pinhole and parallel hole collimation. These models, which are precomputed and stored to disk prior to reconstruction, are based on simple inner-product computations and a region-growing like search defined by the conic view that each detector pixel has of the image voxels. We provide illustrative experimental results based on phantom and mouse data.",

keywords = "Amyloid, Bone scan, Image reconstruction, Single photon emission computed tomography, Small animal imaging, System model",

author = "J. Gregor and T. Benson and S. Gleason and M. Paulus and S. Figueroa and T. Hoffman and S. Kennel and J. Wall",

year = "2006",

month = oct,

doi = "10.1109/TNS.2006.882774",

language = "English",

volume = "53",

pages = "2646--2652",

journal = "IEEE Transactions on Nuclear Science",

issn = "0018-9499",

publisher = "Institute of Electrical and Electronics Engineers",

number = "5",

}

TY - JOUR

T1 - Approximate volumetric system models for MicroSPECT

AU - Gregor, J.

AU - Benson, T.

AU - Gleason, S.

AU - Paulus, M.

AU - Figueroa, S.

AU - Hoffman, T.

AU - Kennel, S.

AU - Wall, J.

PY - 2006/10

Y1 - 2006/10

N2 - A microSPECT system has been developed for the purpose of studying murine models of amyloidosis in vivo. The system is equipped with two detector heads, each consisting of a multi-anode photomultiplier tube coupled to a pixellated NaI(Tl) crystal array. Images are reconstructed using an OS-EM algorithm. In this paper, we describe the associated volumetric system models that we have developed in support of both pinhole and parallel hole collimation. These models, which are precomputed and stored to disk prior to reconstruction, are based on simple inner-product computations and a region-growing like search defined by the conic view that each detector pixel has of the image voxels. We provide illustrative experimental results based on phantom and mouse data.

AB - A microSPECT system has been developed for the purpose of studying murine models of amyloidosis in vivo. The system is equipped with two detector heads, each consisting of a multi-anode photomultiplier tube coupled to a pixellated NaI(Tl) crystal array. Images are reconstructed using an OS-EM algorithm. In this paper, we describe the associated volumetric system models that we have developed in support of both pinhole and parallel hole collimation. These models, which are precomputed and stored to disk prior to reconstruction, are based on simple inner-product computations and a region-growing like search defined by the conic view that each detector pixel has of the image voxels. We provide illustrative experimental results based on phantom and mouse data.

KW - Amyloid

KW - Bone scan

KW - Image reconstruction

KW - Single photon emission computed tomography

KW - Small animal imaging

KW - System model

UR - http://www.scopus.com/inward/record.url?scp=33750410058&partnerID=8YFLogxK

U2 - 10.1109/TNS.2006.882774

DO - 10.1109/TNS.2006.882774

M3 - Article

AN - SCOPUS:33750410058

SN - 0018-9499

VL - 53

SP - 2646

EP - 2652

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

IS - 5

M1 - 1710250

ER -

Approximate volumetric system models for MicroSPECT

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this