All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Jae Hyun Lee; Kyuri Lee; Seung Ho Moon; Yuhan Lee; Tae Gwan Park; Jinwoo Cheon

doi:10.1002/anie.200805998

All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Jae Hyun Lee, Kyuri Lee, Seung Ho Moon, Yuhan Lee, Tae Gwan Park, Jinwoo Cheon

Research output: Contribution to journal › Article › peer-review

338 Scopus citations

Abstract

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

Original language	English
Pages (from-to)	4174-4179
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	23
DOIs	https://doi.org/10.1002/anie.200805998
State	Published - May 25 2009
Externally published	Yes

Keywords

Drug delivery
Magnetic nanoparticles
Magnetic resonance imaging
Multimodal imaging
siRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200805998

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abstract = "Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.",

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AU - Park, Tae Gwan

AU - Cheon, Jinwoo

PY - 2009/5/25

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AB - Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

KW - Drug delivery

KW - Magnetic nanoparticles

KW - Magnetic resonance imaging

KW - Multimodal imaging

KW - siRNA

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All-in-One target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery

Abstract

Keywords

UN SDGs

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