Active higher quality sperm separation using a spiral channel

Jiyoung Son, Odgerel Badamjav, Timothy Jenkins, Bruce Gale, James Hotaling, Douglas Carrell

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This study successfully demonstrated active separation of higher quality sperm from lower quality sperm without using sperm motility by flow-focusing of normally shaped sperm in a spiral channel. Basic principles of spiral channel separations were used to design a specific spiral channel and flow parameters for separating normal shaped sperm. The implemented channel was verified in a series of experiments with fresh semen samples. Viability and morphology test results showed enrichment of higher quality sperm in the outer outlet of the channel and processing caused minimal damage to healthy sperm, showing the potential for this technique to be used clinically.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages376-378
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/TerritoryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Keywords

  • Inertial Microfluidics
  • Sperm
  • Spiral Channel

Fingerprint

Dive into the research topics of 'Active higher quality sperm separation using a spiral channel'. Together they form a unique fingerprint.

Cite this