Abstract
The pathogenesis of multifactorial malignant diseases, with variable onset, severity, and natural history, reflects development-specific exposures and individual responses to these exposures influenced by underlying genetic predisposition. Embedded in life course theory, exposomics provides a framework to more fully elucidate how environmental factors alter cancer risk, disease course, and response to treatment across the lifespan.
| Original language | English |
|---|---|
| Pages (from-to) | 280-282 |
| Number of pages | 3 |
| Journal | Trends in Cancer |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2022 |
Funding
During preparation of this manuscript R.J.W. was supported by UH3OD023337, P30ES023515, and UL1TR001433; H.A.H. was supported by the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C) and the National Cancer Institute (NCI) of the National Institutes of Health DE-AC05-00OR22725. This work was authored, in part, by UT-Battelle, LLC under Contract No. DE-AC05-00OR22725 with the US Department of Energy. The US Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US Government purposes. None declared by authors.
Keywords
- air pollution
- carcinogens
- exposome
- life course theory
- pediatric cancer
- radon