A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging

Pooyan Sahbaee; Ehsan Abadi; Jeremiah Sanders; Marc Becchetti; Yakun Zhang; Greeshma Agasthya; Paul Segars; Ehsan Samei

doi:10.1117/12.2216516

A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging

Pooyan Sahbaee, Ehsan Abadi, Jeremiah Sanders, Marc Becchetti, Yakun Zhang, Greeshma Agasthya, Paul Segars, Ehsan Samei

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

The purpose of this study was to substantiate the interdependency of image quality, radiation dose, and contrast material dose in CT towards the patient-specific optimization of the imaging protocols. The study deployed two phantom platforms. First, a variable sized phantom containing an iodinated insert was imaged on a representative CT scanner at multiple CTDI values. The contrast and noise were measured from the reconstructed images for each phantom diameter. Linearly related to iodine-concentration, contrast to noise ratio (CNR), was calculated for different iodine-concentration levels. Second, the analysis was extended to a recently developed suit of 58 virtual human models (5D-XCAT) with added contrast dynamics. Emulating a contrast-enhanced abdominal image procedure and targeting a peak-enhancement in aorta, each XCAT phantom was "imaged" using a CT simulation platform. 3D surfaces for each patient/size established the relationship between iodine-concentration, dose, and CNR. The Sensitivity of Ratio (SR), defined as ratio of change in iodine-concentration versus dose to yield a constant change in CNR was calculated and compared at high and low radiation dose for both phantom platforms. The results show that sensitivity of CNR to iodine concentration is larger at high radiation dose (up to 73%). The SR results were highly affected by radiation dose metric; CTDI or organ dose. Furthermore, results showed that the presence of contrast material could have a profound impact on optimization results (up to 45%).

Original language	English
Title of host publication	Medical Imaging 2016
Subtitle of host publication	Physics of Medical Imaging
Editors	Despina Kontos, Joseph Y. Lo, Thomas G. Flohr
Publisher	SPIE
ISBN (Electronic)	9781510600188
DOIs	https://doi.org/10.1117/12.2216516
State	Published - 2016
Externally published	Yes
Event	Medical Imaging 2016: Physics of Medical Imaging - San Diego, United States Duration: Feb 28 2016 → Mar 2 2016

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9783
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2016: Physics of Medical Imaging
Country/Territory	United States
City	San Diego
Period	02/28/16 → 03/2/16

Keywords

CTDI
Compartmental Model
Computed Tomography
Contrast Enhanced
Contrast Material
Image Quality
Iodine
Patient Specific
Radiation dose

Access to Document

10.1117/12.2216516

Cite this

Sahbaee, P., Abadi, E., Sanders, J., Becchetti, M., Zhang, Y., Agasthya, G., Segars, P., & Samei, E. (2016). A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging. In D. Kontos, J. Y. Lo, & T. G. Flohr (Eds.), Medical Imaging 2016: Physics of Medical Imaging Article 97833F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9783). SPIE. https://doi.org/10.1117/12.2216516

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abstract = "The purpose of this study was to substantiate the interdependency of image quality, radiation dose, and contrast material dose in CT towards the patient-specific optimization of the imaging protocols. The study deployed two phantom platforms. First, a variable sized phantom containing an iodinated insert was imaged on a representative CT scanner at multiple CTDI values. The contrast and noise were measured from the reconstructed images for each phantom diameter. Linearly related to iodine-concentration, contrast to noise ratio (CNR), was calculated for different iodine-concentration levels. Second, the analysis was extended to a recently developed suit of 58 virtual human models (5D-XCAT) with added contrast dynamics. Emulating a contrast-enhanced abdominal image procedure and targeting a peak-enhancement in aorta, each XCAT phantom was {"}imaged{"} using a CT simulation platform. 3D surfaces for each patient/size established the relationship between iodine-concentration, dose, and CNR. The Sensitivity of Ratio (SR), defined as ratio of change in iodine-concentration versus dose to yield a constant change in CNR was calculated and compared at high and low radiation dose for both phantom platforms. The results show that sensitivity of CNR to iodine concentration is larger at high radiation dose (up to 73%). The SR results were highly affected by radiation dose metric; CTDI or organ dose. Furthermore, results showed that the presence of contrast material could have a profound impact on optimization results (up to 45%).",

keywords = "CTDI, Compartmental Model, Computed Tomography, Contrast Enhanced, Contrast Material, Image Quality, Iodine, Patient Specific, Radiation dose",

author = "Pooyan Sahbaee and Ehsan Abadi and Jeremiah Sanders and Marc Becchetti and Yakun Zhang and Greeshma Agasthya and Paul Segars and Ehsan Samei",

note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Medical Imaging 2016: Physics of Medical Imaging ; Conference date: 28-02-2016 Through 02-03-2016",

year = "2016",

doi = "10.1117/12.2216516",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

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Sahbaee, P, Abadi, E, Sanders, J, Becchetti, M, Zhang, Y, Agasthya, G, Segars, P & Samei, E 2016, A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging. in D Kontos, JY Lo & TG Flohr (eds), Medical Imaging 2016: Physics of Medical Imaging., 97833F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9783, SPIE, Medical Imaging 2016: Physics of Medical Imaging, San Diego, United States, 02/28/16. https://doi.org/10.1117/12.2216516

A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging. / Sahbaee, Pooyan; Abadi, Ehsan; Sanders, Jeremiah et al.
Medical Imaging 2016: Physics of Medical Imaging. ed. / Despina Kontos; Joseph Y. Lo; Thomas G. Flohr. SPIE, 2016. 97833F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9783).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging

AU - Sahbaee, Pooyan

AU - Abadi, Ehsan

AU - Sanders, Jeremiah

AU - Becchetti, Marc

AU - Zhang, Yakun

AU - Agasthya, Greeshma

AU - Segars, Paul

AU - Samei, Ehsan

PY - 2016

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N2 - The purpose of this study was to substantiate the interdependency of image quality, radiation dose, and contrast material dose in CT towards the patient-specific optimization of the imaging protocols. The study deployed two phantom platforms. First, a variable sized phantom containing an iodinated insert was imaged on a representative CT scanner at multiple CTDI values. The contrast and noise were measured from the reconstructed images for each phantom diameter. Linearly related to iodine-concentration, contrast to noise ratio (CNR), was calculated for different iodine-concentration levels. Second, the analysis was extended to a recently developed suit of 58 virtual human models (5D-XCAT) with added contrast dynamics. Emulating a contrast-enhanced abdominal image procedure and targeting a peak-enhancement in aorta, each XCAT phantom was "imaged" using a CT simulation platform. 3D surfaces for each patient/size established the relationship between iodine-concentration, dose, and CNR. The Sensitivity of Ratio (SR), defined as ratio of change in iodine-concentration versus dose to yield a constant change in CNR was calculated and compared at high and low radiation dose for both phantom platforms. The results show that sensitivity of CNR to iodine concentration is larger at high radiation dose (up to 73%). The SR results were highly affected by radiation dose metric; CTDI or organ dose. Furthermore, results showed that the presence of contrast material could have a profound impact on optimization results (up to 45%).

AB - The purpose of this study was to substantiate the interdependency of image quality, radiation dose, and contrast material dose in CT towards the patient-specific optimization of the imaging protocols. The study deployed two phantom platforms. First, a variable sized phantom containing an iodinated insert was imaged on a representative CT scanner at multiple CTDI values. The contrast and noise were measured from the reconstructed images for each phantom diameter. Linearly related to iodine-concentration, contrast to noise ratio (CNR), was calculated for different iodine-concentration levels. Second, the analysis was extended to a recently developed suit of 58 virtual human models (5D-XCAT) with added contrast dynamics. Emulating a contrast-enhanced abdominal image procedure and targeting a peak-enhancement in aorta, each XCAT phantom was "imaged" using a CT simulation platform. 3D surfaces for each patient/size established the relationship between iodine-concentration, dose, and CNR. The Sensitivity of Ratio (SR), defined as ratio of change in iodine-concentration versus dose to yield a constant change in CNR was calculated and compared at high and low radiation dose for both phantom platforms. The results show that sensitivity of CNR to iodine concentration is larger at high radiation dose (up to 73%). The SR results were highly affected by radiation dose metric; CTDI or organ dose. Furthermore, results showed that the presence of contrast material could have a profound impact on optimization results (up to 45%).

KW - CTDI

KW - Compartmental Model

KW - Computed Tomography

KW - Contrast Enhanced

KW - Contrast Material

KW - Image Quality

KW - Iodine

KW - Patient Specific

KW - Radiation dose

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DO - 10.1117/12.2216516

M3 - Conference contribution

AN - SCOPUS:84978909369

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Medical Imaging 2016

A2 - Kontos, Despina

A2 - Lo, Joseph Y.

A2 - Flohr, Thomas G.

PB - SPIE

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ER -

Sahbaee P, Abadi E, Sanders J, Becchetti M, Zhang Y, Agasthya G et al. A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging. In Kontos D, Lo JY, Flohr TG, editors, Medical Imaging 2016: Physics of Medical Imaging. SPIE. 2016. 97833F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2216516

A technique for multi-dimensional optimization of radiation dose, contrast dose, and image quality in CT imaging

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Keywords

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